The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

著者: Daniel N. Meijles, Sanghamitra Sahoo, Imad Al Ghouleh, Jefferson H. Amaral, Raquel Bienes-Martínez, Heather E. Knupp, Shireen Attaran, John Sembrat, Mehdi Nouraie, Mauricio Rojas, Enrico M. Novelli, Mark T. Gladwin, Jeffrey S. Isenberg, Eugenia Cifuentes-Pagano, Patrick J. Pagano - Science Signaling 2017 被引用: 94

Finally, genetic ablation or pharmacological blockade of Nox1 in human endothelial cells attenuated TSP1-mediated ROS generation, restored cell cycle progression, and protected against senescence. Together, our results provide insights into the functional interplay between TSP1 and Nox1 in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.