Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

著者: Pedro Moura‐Alves, Andreas Puyskens, Anne Stinn, Marion Klemm, Ute Guhlich‐Bornhof, Anca Dorhoi, Jens Furkert, Annika Kreuchwig, Jonas Protze, Laura Lozza, Gang Pei, Philippe Saikali, Carolina Perdomo, Hans‐Joachim Mollenkopf, Robert Hurwitz, Frank Kirschhoefer, Gerald Brenner‐Weiß, January Weiner, Hartmut Oschkinat, Michael Kolbe, Gerd Krause, Stefan H. E. Kaufmann - Science 2019 被引用: 164

Spying on bacterial signals Many bacteria produce small molecules for monitoring population density and thus regulating their collective behavior, a process termed quorum sensing. Pathogens like Pseudomonas aeruginosa , which complicates cystic fibrosis disease, produce different quorum-sensing ligands at different stages of infection. Moura-Alves et al. used experiments in human cells, zebrafish, and mice to show that a host organism can eavesdrop on these bacterial conversations. A host sensor responds differentially to bacterial quorum-sensing molecules to activate or repress different response pathways. The ability to “listen in” on bacterial signaling provides the host with the capacity to fine-tune physiologically costly immune responses. Science , this issue p. eaaw1629