Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank

著者: Elvis A. Akwo, Hua‐Chang Chen, Ge Liu, Jefferson L. Triozzi, Ran Tao, Zhihong Yu, Cecilia P. Chung, Ayush Giri, T. Alp İkizler, Christoph Stein, Edward D. Siew, QiPing Feng, Cassianne Robinson‐Cohen, Adriana M. Hung - Kidney International Reports 2022 被引用: 19

Introduction: variant-phenotype associations across population groups are unclear. Methods: variants and up to 1528 clinical diagnosis codes mapped to phenotype groups in the Million Veteran Program (MVP), using published phenome-wide association study (PheWAS) methodology. Associations were tested using logistic regression adjusted for age, sex, and 10 principal components of ancestry. Bonferroni correction for multiple comparisons was applied. Results: promoter variants were attenuated. Conclusion: variants linked with increased uromodulin expression and lower odds of UTIs and calculus and increased odds of CKD and hypertension. However, these associations varied significantly across ancestry groups and sex.