Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis

著者: Maximillian A. Rogers, Fabrizio Buffolo, Florian Schlotter, Samantha K. Atkins, Lang Ho Lee, Arda Halu, Mark C. Blaser, Elena Tsolaki, Hideyuki Higashi, Kristin Luther, George G. Daaboul, Carlijn V. C. Bouten, Simon C. Body, Sasha A. Singh, Sérgio Bertazzo, Peter Libby, Masanori Aikawa, Elena Aïkawa - Science Advances 2020 被引用: 114

knockdown attenuated EV aggregation and microcalcification formation in human cardiovascular cells and acellular three-dimensional collagen hydrogels. Our findings explain why microcalcifications are more prone to form in vulnerable regions of plaque, regulating critical cardiovascular pathology, and likely extend to other EV-associated diseases, including autoimmune and neurodegenerative diseases and cancer.