Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

著者: Lian Dee Ler, Sujoy Ghosh, Xiaoran Chai, Aye Aye Thike, Hong Lee Heng, Ee Yan Siew, Sucharita Dey, Liang Kai Koh, Jing Quan Lim, Weng Khong Lim, Swe Swe Myint, Jia Liang Loh, Pauline Ong, Xin Xiu Sam, Dachuan Huang, Tony Kiat Hon Lim, Puay Hoon Tan, Sanjanaa Nagarajan, Christopher Wai Sam Cheng, Henry Sun Sien Ho, Lay Guat Ng, J.S.P. Yuen, Po‐Hung Lin, Cheng‐Keng Chuang, Ying‐Hsu Chang, Wen‐Hui Weng, Steve Rozen, Patrick Tan, Caretha L. Creasy, See‐Tong Pang, Michael T. McCabe, Song Ling Poon, Bin Tean Teh - Science Translational Medicine 2017 被引用: 211

, which are common in urothelial bladder carcinoma, are potentially targetable by inhibiting EZH2.