Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration

著者: Erich Tusch, Lene Ryom, Annegret Pelchen–Matthews, Amanda Mocroft, Daniel Elbirt, Cristiana Oprea, Huldrych F. Günthard, Cornelia Staehelin, Robert Zangerle, Isabelle Suárez, Jörg Janne Vehreschild, Ferdinand Wit, Marianna Menozzi, Antonella d'Arminio Monforte, Vincenzo Spagnuolo, Christian Pradier, Christina Carlander, Paula Suanzes, Jan‐Christian Wasmuth, Andrew Carr, Kathy Petoumenos, Frauke Borgans, Fabrice Bonnet, Stéphane De Wit, Wafaa El‐Sadr, Bastian Neesgaard, Nadine Jaschinski, Lauren Greenberg, Sean R Hosein, Joel E. Gallant, Vani Vannappagari, Lital Young, Caroline Sabin, Jens Lundgren, Lars Peters, Joanne Reekie, D:A:D cohort study, W El-Sadr, G Calvo, Fidéline Bonnet-Serrano, F Dabis, O Kirk, A Mocroft, Matthew Law, A d’Arminio Monforte, Linda Morfeldt, C Pradier, P Reiss, R Weber, S De Wit, A Lind-Thomsen, Rikke Brandt, M Hillebreght, S Zaheri, F W N M Wit, Alexandra Scherrer, F. Schöni-Affolter, Martin Rickenbach, Alessandro Tavelli, Iuri Fanti, O Leleux, J. Mourali, F Le Marec, Eloïse Boerg, Eva Thulin, A Sundström, Georg Bartsch, G Thompsen, Coca Necsoi, M Delforge, E Fontas, C Caissotti, K Dollet, S Mateu, Ferràn Torres, K Petoumenos, A Blance, Robin Huang, R Puhr, Kamilla Grønborg Laut, Daniel Tuyet Kristensen, Caroline Sabin, Andrew Phillips, D A Kamara, C J Smith, A Mocroft, C I Hatleberg, A Lind-Thomsen, Rikke Brandt, D Raben, Charles E. Matthews, Anders Bojesen, Anne Louise Grevsen, J D Lundgren, L Ryom, William G. Powderly, N. Shortman, Christiane Moecklinghoff, Gerry Reilly, Xavier Franquet, L Ryom, A Mocroft, Ole Kirk, P Reiss, Colette Smit, M Ross, C A Fux, P Morlat, E Fontas, David A Kamara, C J Smith, J D Lundgren, C J Smith, L Ryom, Camilla Ingrid Hatleberg, A. N. Phillips, Richard D Weber, P Morlat, C Pradier, P Reiss, F W N M Wit, Nina Friis‐Møller, Justyna Kowalska, J D Lundgren, Caroline Sabin, L Ryom, C I Hatleberg, Matthew Law, A d’Arminio Monforte, F Dabis, F Bonnet, P Reiss, Ferdinand W N M Wit, Colette Smith, D A Kamara, Julia Bohlius, Mark Bower, G Fätkenheuer, Andrew E. Grulich, Jens Lundgren, Anette Sjøl, P. Meidahl, J-G. Iversen, Central P Reiss, S Zaheri, M Hillebregt, F W N M Wit, Jan M. Prins, TW Kuijpers, H. J. Scherpbier, Jan T. M. van der Meer, F W N M Wit, Mieke H. Godfried, P Reiss, T. van der Poll, F.J.B. Nellen, Suzanne E. Geerlings, Michèle van Vugt, Dasja Pajkrt, Jeannet C. Bos, W. Joost Wiersinga, Marc van der Valk, Abraham Goorhuis, Joppe W. Hovius, J. van Eden, A. Henderiks, A M H van Hes, M Mutschelknauss, H. Nobel, F J J Pijnappel, Suzanne Jurriaans, Nicole Back, Hans L. Zaaijer, Ben Berkhout, Marion Cornelissen, C. Schinkel, X V Thomas, Admiraal De Ruyter Ziekenhuis, Maarten van den Berge, Arjan Stegeman, S. Baas, L. Hage de Looff, Donald J. Versteeg, Catharina Ziekenhuis, M.J.H. Pronk, Heidi Ammerlaan, E.S. de Munnik, A R Jansz, Jeroen H. T. Tjhie, M.C.A. Wegdam, Birgit Deiman, Volkher Scharnhorst, A. van der Plas, Annouschka M. Weijsenfeld, M E van der Ende, T.E.M.S. de Vries-Sluijs, Eric C. M. Van Gorp, Carolina A. M. Schurink, Jan Nouwen, Annelies Verbon, Bart Rijnders, Hannelore I. Bax, M. van der Feltz, N. Bassant, J.E.A. van Beek, M. Vriesde, L.M. van Zonneveld, A de Oude-Lubbers, H J van den Berg-Cameron, F B Bruinsma-Broekman, Joris R. de Groot, M de Zeeuw- de Man, Charles A. Boucher, Marion Koopmans, Jeroen J. A. van Kampen, Suzan D. Pas, Erasmus MC–Sophia, Gertjan J. A. Driessen, Annemarie M. C. van Rossum, Linda C. van der Knaap, Eline G. Visser, Judith Branger, A Rijkeboer-Mes, C.J.H.M. Duijf-van de Ven, Haga Ziekenhuis, Emile F. Schippers, Cees van Nieuwkoop, J M van IJperen, J. Geilings, G. van der Hut, Paul Franck, Arne van Eeden, W. Brokking, Marco R. de Groot, L. Elsenburg, M. Damen, I S Kwa, P. H. P. Groeneveld, J.W. Bouwhuis, Julia F. van den Berg, A. G. W. van Hulzen, G.L. van der Bliek, Petra Bor, Peter Bloembergen, M. J. H. M. Wolfhagen, G J H M Ruijs, Frank P. Kroon, Mark de Boer, Marlies Bauer, H. Jolink, Albert M. Vollaard, W Dorama, Natasja van Holten, Eric C. J. Claas, Els Wessels, Jan G. den Hollander, Katalin Pogány, Anna H.E. Roukens, M Kastelijns, J.V. Smit, Erasmus Smit, D. Struik-Kalkman, C. Tearno, M. Bezemer, T.G.C.M. van Niekerk, Oscar Pontesilli, S.H. Lowe, Astrid M. L. Oude Lashof, Dirk Posthouwer, Robin Ackens, J. Schippers, R Vergoossen, B. Weijenberg-Maes, Inge H. M. van Loo, Thomas Havenith, Eliane M.S. Leyten, L. B. S. Gelinck, A van Hartingsveld, C Meerkerk, G.S. Wildenbeest, J. A. E. M. Mutsaers, C. Jansen, Jan W. Mulder, S.M.E. Vrouenraets, Fanny N. Lauw, Michelle Broekhuizen, H Paap, D J Vlasblom, Paul H.M. Smits, M C Zuiderzee, Sebastiaan Weijer, Rachida el Moussaoui, A S Bosma, Marit G. A. van Vonderen, D P F van Houte, Linda M. Kampschreur, Kyra L. Dijkstra, Sonya C. Faber, Jan Weel, G. J. Kootstra, Corine Delsing, Matthijs Plas, Henry C. Heins, Eric Lucas, W. Kortmann, G. van Twillert, J. W. T. Cohen Stuart, B. M. W. Diederen, D Pronk, F.A. van Truijen-Oud, Wil A. van der Reijden, R Jansen, Kees Brinkman, G.E.L. van den Berk, Willem L. Blok, P. H. J. Frissen, Kamilla D. Lettinga, W.E.M. Schouten, Jan A. Veenstra, C.J. Brouwer, G.F. Geerders, K Hoeksema, M.J. Kleene, I.B. van der Meché, M E Spelbrink, H Sulman, A.J.M. Toonen, S. Wijnands, M. Damen, David Kwa, Emily Witte, P.P. Koopmans, Monique Keuter, Andre J. A. M. van der Ven, H.J.M. ter Hofstede, A. Dofferhoff, Reinout van Crevel, M. Albers, M E W Bosch, K.J.T. Grintjes-Huisman, B. Zomer, Foekje F. Stelma, Janette Rahamat‐Langendoen, David M. Burger, Clemens Richter, Elisabeth H. Gisolf, Robert‐Jan Hassing, G. ter Beest, P.H.M. van Bentum, Nienke Langebeek, R. Tiemessen, C.M.A. Swanink, S.F.L. van Lelyveld, Robert Soetekouw, N Hulshoff, L.M.M. van der Prijt, J. van der Swaluw, N. Bermon, Wil A. van der Reijden, R Jansen, Bjorn L. Herpers, Dick Veenendaal, D.W.M. Verhagen, Michiel P. van Wijk, St Elisabeth Ziekenhuis, M.E.E. van Kasteren, A.E. Brouwer, B.A.F.M. de Kruijf-van de Wiel, Mirjam Kuipers, R M W J Santegoets, B van der Ven, J. H. Marcelis, A. G. M. Buiting, Peter Kabel, Wouter F.W. Bierman, H Scholvinck, K R Wilting, Ymkje Stienstra, H. de Jonge, P A van der Meulen, D.A. de Weerd, Janneke Ludwig-Roukema, Hubert G.M. Niesters, Annelies Riezebos‐Brilman, Coretta van Leer‐Buter, Marjolein Knoester, A. I. M. Hoepelman, Tania Mudrikova, Pauline M. Ellerbroek, Jan Jelrik Oosterheert, Joop E. Arends, Roos E. Barth, M.W.M. Wassenberg, E.M. Schadd, D H M van Elst-Laurijssen, Esther E. B. van Oers-Hazelzet, Sigrid C. J. M. Vervoort, Miranda van Berkel, Rob Schuurman, F. Verduyn-Lunel, Annemarie M. J. Wensing, Edgar J.G. Peters, Michiel A. van Agtmael, Marije K. Bomers, J. de Vocht, M. Heitmuller, Liedewij Laan, Annika Pettersson, Christina M. J. E. Vandenbroucke‐Grauls, C. Wim Ang, Wilhelmina Kinderziekenhuis, Sibyl P. M. Geelen, Tom F.W. Wolfs, Louis Bont, N Nauta, P Reiss, D.O. Bezemer, A.I. van Sighem, Colette Smit, Ferdinand W N M Wit, T. Sonia Boender, S Zaheri, M Hillebregt, A. de Jong, D.P. Bergsma, P. Hoekstra, A de Lang, S Grivell, Angelique C.M. Jansen, Marius Rademaker, M Raethke, Roelien A. M. Meijering, S Schnörr, C.P.G.M. de Groot, Marjan van den Akker, Y. Bakker, E Claessen, A el Berkaoui, Judith C. Koops, E Kruijne, C.R.E. Lodewijk, L. Munjishvili, B Peeck, Cornelis L. P. van de Ree, R. Regtop, Y M C Ruijs, T. Rutkens, Linette Sande, Maartje Schoorl, A Timmerman, E. Tuijn, L Veenenberg, Stefan van der Vliet, Agatha Wisse, T.J. Woudstra, Bert Tuk, F Bonnet, F Dabis, M Dupon, Valérie Gaborieau, D Lacoste, Denis Malvy, P Mercié, P Morlat, David B. Neau, J L Pellegrin, S Tchamgoué, Estibaliz Lazaro, Charles Cazanave, Marrie-Anne Vandenhende, Marc-Olivier Vareil, Y Gérard, P Blanco, Stéphane Bouchet, Dominique Breilh, H. Fleury, I Pellegrin, Geneviève Chêne, R Thiébaut, Linda Wittkop, Linda Wittkop, O Leleux, S. Lawson‐Ayayi, Anne Gimbert, S Desjardin, L. Lacaze-Buzy, Ventzislava Petrov–Sanchez, Fidéline Bonnet-Serrano, Geneviève Chêne, F Dabis, R Thiébaut, Linda Wittkop, K André, N. Bernard, F Bonnet, O. Caubet, L. Caunègre, Charles Cazanave, I. Chossat, C Courtault, F. Dauchy, S Witte, D. Dondia, M Dupon, P. Duffau, H. Dutronc, Sophie Farbos, I. Faure, H. Ferrand, Valérie Gaborieau, Y Gérard, C. Greib, Mojgan Hessamfar, Yoannis Imbert, D Lacoste, P Lataste, Estibaliz Lazaro, Denis Malvy, J Marie, M Mechain, P Mercié, É. Monlun, P Morlat, David B. Neau, Anthony Ochoa, J L Pellegrin, Thierry Pistone, I. Raymond, M. C. Receveur, P Rispal, L. Sorin, S Tchamgoué, Clarisse Audigier-Valette, Marie-Anne Vandenhende, Marc-Olivier Vareil, Jean‐François Viallard, H. Wille, Grégory J. Wirth, I Pellegrin, P Blanco, H. Fleury, Me Lafon, Pascale Trimoulet, Pantxika Bellecave, Camille Tumiotto, Stéphane Bouchet, Dominique Breilh, Françoise Haramburu, G. Miremeont-Salamé, M. J. Blaizeau, M. Decoin, C. Hannapier, E. Lenaud, A. Pougetoux, Sandrine Delveaux, C d'Ivernois, F. Diarra, B. Uwamaliya-Nziyumvira, Olivier Leleux, F Le Marec, Eloïse Boerg, S. Lawson‐Ayayi, Gary A. Palmer, V. Conte, Vincent Sapparrart, Central M Law, Kathy Petoumenos, R Puhr, Robin Huang, Rod Moore, S Edwards, Jennifer Hoy, K. Watson, N Roth, H. Lau, M Bloch, David Baker, Andrew Carr, David A. Cooper, Maria OʼSullivan, David Nolan, Gabriella Guelfi, C Calvo, Ferràn Torres, S Mateu, Pere Domingo, M. A. Sambeat, J Gatell, Elena del Cacho, Josep Puig i Cadafalch, M Fúster, Carles Codina, G. Sirera, A. Vaqué, S De Wit, Nathan Clumeck, M Delforge, Coca Necsoi, N Clumeck, Stéphane De Wit, Anne-Françoise Gennotte, M Gerard, K Kabeya, Déborah Konopnicki, Agnès Libois, C Martin, M.C. Payen, Pascal Semaille, Y Van Laethem, Stéphane De Wit, N Clumeck, M Delforge, Coca Necsoi, N Clumeck, S De Wit, Anne-Françoise Gennotte, M Gerard, K Kabeya, Déborah Konopnicki, Agnès Libois, C Martin, M.C. Payen, Pascal Semaille, Y Van Laethem, Central J Neaton, Georg Bartsch, W El-Sadr, Everson Augusto Krum, G. Thompson, Deborah Wentworth, Roberta Luskin‐Hawk, Edward E. Telzak, W El-Sadr, Donald I. Abrams, Danny M. Cohn, Norman Markowitz, Roberto C. Arduino, David Mushatt, G. Friedland, Gonzalo Pérez, Ellen Tedaldi, E S Fisher, Fred M. Gordin, Lawrence R. Crane, John J. Sampson, J Baxter, J Gatell, Brian Gazzard, A Horban, Igor Karpov, M Losso, A d’Arminio Monforte, C. Pedersen, Matti Ristola, Andrew Phillips, P Reiss, J Lundgren, J Rockstroh, J Rockstroh, A Mocroft, O Kirk, O Kirk, Lars Peters, Charles E. Matthews, Andrew H. Fischer, Anders Bojesen, D Raben, Daniel Tuyet Kristensen, Kamilla Grønborg Laut, Jens Fromholt Larsen, Daria Podlekareva, A Mocroft, Andrew Phillips, Alessandro Cozzi‐Lepri, Leah Shepherd, A. B. Schultze, Sarah Amele, M Losso, M Kundro, Brigitte Schmied, Pulmologisches Zentrum der Stadt Wien, Robert Zangerle, Igor Karpov, Anna Vassilenko, В. М. Мицура, D. Paduto, Nathan Clumeck, S. De Wit, M Delforge, Éric Florence, Linos Vandekerckhove, Vesna Hadžiosmanović, Josip Begovać, Ladislav Machala, David Jilich, Dalibor Sedláček, Gitte Kronborg, Thomas Benfield, Jan Gerstoft, Terese L. Katzenstein, N F Møller, C. Pedersen, Lars Østergaard, Lothar Wiese, Lars N. Nielsen, Kai Zilmer, Jelena Šmidt, Nakkusosakond Siseklinik, Matti Ristola, Inka Aho, J-P Viard, C Pradier, Éric Fontas, Claudine Duvivier, J Rockstroh, Ralf Schmidt, Olaf Degen, H J Stellbrink, Daniela Cristina Stefan, John W. Goethe, J. R. Bogner, G Fätkenheuer, Nikoloz Chkhartishvili, P. Gargalianos, G. Xylomenos, K. Armenis, Helen Sambatakou, János Szlávik, Magnús Gottfreðsson, F Mulcahy, Israel Yust, Dan Turner, Michael Burke, Eduardo Shahar, Gamal Hassoun, Hila Elinav, M Haouzi, Daniel Elbirt, Zev Sthoeger, A D’Arminio Monforte, Roberta Esposito, I. Mazeu, C Mussini, Francesco Mazzotta, Andrea Gabbuti, Ospedale S Maria Annunziata, Vincenzo Vullo, M Lichtner, Mauro Zaccarelli, A Antinori, R Acinapura, Maria Maddalena Plazzi, A Lazzarin, Antonella Castagna, Nicola Gianotti, Massimo Galli, Anna Lisa Ridolfo, B Rozentale, Vilma Uždavinienė, Raimonda Matulionytė, Thérèse Staub, R Hemmer, P Reiss, Vidar Ormaasen, A Mæland, JN Bruun, Brygida Knysz, Jacek Gąsiorowski, Małgorzata Inglot, A Horban, Elżbieta Bąkowska, Robert Flisiak, Anna Grzeszczuk, Miłosz Parczewski, Katarzyna Maciejewska, Bogusz Aksak‐Wąs, Marek Beniowski, E. Mularska, Tomasz Smiatacz, M Gensing, Elżbieta Jabłonowska, Ewa Małolepsza, Kamila Wójcik, Iwona Mozer‐Lisewska, L. Caldeira, Kamal Mansinho, Fernando Maltêz, Roxana Rădoi, Cristiana Oprea, Alexander Panteleev, O. O. Panteleev, A. V. Yakovlev, T. Trofimora, Irina Khromova, Elena Kuzovatova, I N Blokhina, Nizhny Novogrod, Е. А. Бородулина, Е. С. Вдоушкина, Djordje Jevtović, Janez Tomažič, José M. Gatell, José M. Miró, Santiago Moreno, José Manuel Ramírez Rodriguez, B Clotet, A. Jou, Roger Paredes, Cristina Tural, Jordi Puig, Isabel Bravo, Pere Domingo, María J. Gutiérrez, Gràcia Mateo, M. A. Sambeat, Jean-Marc Laporte, Christina Carlander, Anders Sönnerborg, Inger Brännström, Leo Flamholc, Alexandra Scherrer, Richard D Weber, M Cavassini, A Calmy, H Furrer, M Battegay, Patrick Schmid, Anastasiia Kuznetsova, Galina Kyselyova, M Sluzhynska, Brian Gazzard, Margaret Johnson, Erica Simons, S Edwards, Andrew Phillips, M. A. Johnson, A Mocroft, Chloe Orkin, João Luís Almeida Weber, G Scullard, Amanda Clarke, Clifford Leen, Central L Morfeldt, Gunilla Thulin, A Sundström, Börje Åkerlund, Kadri Koppel, A Karlsson, Leo Flamholc, C. Håkangård, A d’Arminio Monforte, Andrea Antinori, A Castagna, Francesco Castelli, Roberto Cauda, Giovanni Di Perri, Massimo Galli, R Iardino, Giuseppe Ippolito, Giulia Marchetti, Carlo Federico Perno, F von Schloesser, P Viale, A d’Arminio Monforte, A Antinori, A Castagna, Francesca Ceccherini‐Silberstein, Alessandro Cozzi‐Lepri, Enrico Girardi, Sergio Lo Caputo, C Mussini, Massimo Puoti, Massimo Andreoni, Adriana Ammassari, Andrea Antinori, Claudia Balotta, Alessandra Bandera, Paolo Bonfanti, Stefano Bonora, Marco Borderi, Andrea Calcagno, Leonardo Calza, Maria Rosaria Capobianchi, A Castagna, Francesca Ceccherini‐Silberstein, Antonella Cingolani, Paola Cinque, Alessandro Cozzi‐Lepri, Antonella d’Arminio Monforte, A De Luca, Antonio Di Biagio, Enrico Girardi, Nicola Gianotti, Andrea Gori, Giovanni Guaraldi, Giuseppe Lapadula, M Lichtner, Sergio Lo Caputo, G Madeddu, F Maggiolo, G Marchetti, S Marcotullio, Laura Monno, C Mussini, Silvia Nozza, Massimo Puoti, Eugenia Quirós-Roldán, Roberto Rossotti, Stefano Rusconi, Maria Mercedes Santoro, Annalisa Saracino, Mauro Zaccarelli, Alessandro Cozzi‐Lepri, Iuri Fanti, Laura Galli, Patrizia Lorenzini, A Rodano, Milensu Shanyinde, Alessandro Tavelli, Fabrizio Carletti, Silvia Carrara, Antonino Di, Silvia Graziano, Fabrizio Petrone, Gennaro Prota, Serena Quartu, S Truffa, Andrea Giacometti, Andrea Costantini, V Barocci, Gioacchino Angarano, Laura Monno, Carmen Rita Santoro, F Maggiolo, Claudia Suardi, P Viale, Valentina Donati, Gabriella Verucchi, Francesco Castelli, C Minardi, Eugenia Quirós-Roldán, Tiziana Quirino, C Abeli, Paolo Emilio Manconi, P Piano, Bruno Cacopardo, Benedetto Maurizio Celesia, Jacopo Vecchiet, Katia Falasca, Angelo Pan, Silvia Lorenzotti, L Sighinolfi, Daniela Segala, Francesco Mazzotta, Francesca Vichi, Giovanni Cassola, Claudio Viscoli, A. Alessandrini, Nicoletta Bobbio, Giovanni Mazzarello, Claudio Maria Mastroianni, Valeria Belvisi, Paolo Bonfanti, Ilaria Caramma, Alessandro Chiodera, P Milini, A d’Arminio Monforte, Massimo Galli, A Lazzarin, Giuliano Rizzardini, Massimo Puoti, A Castagna, G Marchetti, M C Moioli, R. Piolini, Anna Lisa Ridolfo, Stefania Salpietro, Camilla Tincati, C Mussini, Cinzia Puzzolante, Andrea Gori, Giuseppe Lapadula, N Abrescia, Antonio Chirianni, Guglielmo Borgia, Rosalba Orlando, Giovanni Bonadies, Federica Martino, Ivan Gentile, L Maddaloni, Anna Maria Cattelan, Serena Marinello, Antonio Cascio, Claudia Colomba, Franco Baldelli, Elisabetta Schiaroli, Giustino Parruti, F Sozio, G. Magnani, M A Ursitti, Massimo Andreoni, Andrea Antinori, Roberto Cauda, Antonio Cristaudo, Vincenzo Vullo, R Acinapura, Gianmaria Baldin, M Capozzi, S Cicalini, Antonella Cingolani, Lucia Fontanelli Šuleková, Giancarlo Iaiani, Alessandra Latini, Ilaria Mastrorosa, Maria Maddalena Plazzi, Stefano Savinelli, Alessandra Vergori, M Cecchetto, Franco Viviani, G Madeddu, Paola Bagella, A De Luca, Barbara Rossetti, Alfredo Franco‐Obregón, Rosario Vecchio, Daniela Francisci, C Di Giuli, P Caramello, Giovanni Di Perri, Stefano Bonora, Giancarlo Orofino, Mauro Sciandra, Matteo Bassetti, AP Londero, G. Pellizzer, Vinicio Manfrin, Giulio Starnini, A Ialungo, Ctce Central, E Fontas, K Dollet, C Caissotti, P. Dellamonica, E Bernard, Johan Courjon, Éric Cua, F. De Salvador-Guillouët, Joël M. Durant, C Etienne, Sara Ferrando, V. Mondain-Miton, Atta Abbas Naqvi, I. Perbost, Sylvie Pillet, B Prouvost-Keller, Pellegrina Pugliese, V Rio, Karine Risso, P. Roger, Vincent Aubert, M Battegay, Enos Bernasconi, Jürg Böni, Dominique L. Braun, Heiner C. Bucher, A Calmy, M Cavassini, Angela Ciuffi, G Dollenmaier, M Egger, Luigia Elzi, J Fehr, Jacques Fellay, H Furrer, C A Fux, Huldrych F. Günthard, D Haerry, Barbara Hasse, Hans H. Hirsch, Matthias Hoffmann, Irène Hösli, Christian R. Kahlert, Laurent Kaiser, Olivia Keiser, Thomas Klimkait, Roger D. Kouyos, Helen Kovari, Bruno Ledergerber, G Martinetti, Begoña Martínez de Tejada, Catia Marzolini, Karin J. Metzner, N Müller, Dunja Nicca, G Pantaleo, P Paioni, Alan Rauch, Charles M. Rudin, Alexandra Scherrer, Patrick Schmid, Roberto F. Speck, M Stöckle, Philip Tarr, Alexandra Trkola, P Vernazza, Gilles Wandeler, R Weber, Sabine Yerly, RESPOND cohort study, Ferdinand Wit, Marc vd Valk, M Hillebregt, K Petoumenos, Matthew Law, J Hutchinson, Dhanushi Rupasinghe, W Min Han, Robert Zangerle, H Appoyer, Jaime H. Vera, Amanda Clarke, B Broster, L Barbour, D Carney, L Greenland, Robert J. Coughlan, Cecilia Saint-Pierre, S De Wit, M Delforge, Josip Begovać, Gilles Wandeler, C Stephan, M Bucht, Nikoloz Chkhartishvili, Otar Chokoshvili, A d’Arminio Monforte, A Rodano, Alessandro Tavelli, Iuri Fanti, C Mussini, Vanni Borghi, C Pradier, E Fontas, K Dollet, C Caissotti, J Casabona, José M. Miró, C Smith, Fiona Lampe, Michael P. Johnson, Fiona Burns, C Chaloner, A Castagna, Vincenzo Spagnuolo, Camilla Muccini, Silvia Nozza, Riccardo Lolatto, Anders Sönnerborg, Christina Carlander, Piotr Nowak, Jan Vesterbacka, L.‐Å. Mattsson, D Carrick, K Stigsäter, H Günthard, K Kusejko, Bruno Ledergerber, Heiner C. Bucher, J C Wasmuth, J Rockstroh, Jörg Janne Vehreschild, G Fätkenheuer, Nick Schulze, Bernd Franke, Lene Ryom, M Law, J Rooney, Ian R. McNicholl, Vani Vannappagari, H Garges, Kathy Petoumenos, Gilles Wandeler, Robert Zangerle, C Smith, S De Wit, Jens Lundgren, Huldrych F. Günthard, Lynn Young, Rafael Del Campo, Jens Lundgren, H Günthard, Justyna Kowalska, D Raben, L Ryom, J Rockstroh, L Peters, O Kirk, Daria Podlekareva, Alain Volny‐Anne, N Dedes, E. D. Williams, Nikoloz Chkhartishvili, Robert Zangerle, K Petoumenos, Ferdinand Wit, C Necsoi, G Wandeler, C Stephan, C Pradier, A D’Arminio Monforte, C Mussini, Andreu Bruguera, Heiner C. Bucher, Anders Sönnerborg, Jörg Janne Vehreschild, J C Wasmuth, C Smith, A Castagna, Jaime H. Vera, J Rooney, Ian R. McNicholl, Vani Vannappagari, H Garges, Josip Begovać, Lynn Young, R Campo Alain Volny-Anne, Nikos Dedes, Luís Mendão, Jens Fromholt Larsen, L Peters, Nadine Jaschinski, A Timiryasova, Bastian Neesgaard, O Fursa, L Ryom, Marie Louise Jakobsen, Christian Kraef, M Gardizi, David Raben, Kristian Andersen, Lalitesh Kumar, T W Elsing, S. Shahi, Olena Valdenmaiier, Joanne Reekie, Lauren Greenberg, Loveleen Bansi‐Matharu, Annegret Pelchen–Matthews, K Petoumenos, D Byonanebye, Erich Tusch, Wendy Bannister, Ashley Roen - Clinical Infectious Diseases 2024 被引用: 29

BACKGROUND: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. METHODS: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. RESULTS: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI, .96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI, .95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI, .96-1.05). Mortality due to all known causes except NADM also declined. CONCLUSIONS: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.