Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

著者: Tammy Song, Maarja-Liisa Nairismägi, Yurike Laurensia, Jing Quan Lim, Jing Tan, Zhi-Mei Li, Wan‐Lu Pang, Atish Kizhakeyil, Giovani-Claresta Wijaya, Da-Chuan Huang, Sanjanaa Nagarajan, Burton Kuan Hui Chia, Daryl Ming Zhe Cheah, Yan Hui Liu, Fen Zhang, Hui-Lan Rao, Tiffany Tang, Esther Kam-Yin Wong, Jin‐Xin Bei, Jabed Iqbal, Nicholas-Francis Grigoropoulos, Siok‐Bian Ng, Wee Joo Chng, Bin Tean Teh, Soo‐Yong Tan, Navin Kumar Verma, Hao Fan, Soon Thye Lim, Choon Kiat Ong - Blood 2018 被引用: 321

mutant NKTL cell lines. In NKTL tumors, STAT3 activation correlated significantly with PD-L1 expression. We demonstrated that STAT3 activation confers high PD-L1 expression, which may promote tumor immune evasion. The combination of PD-1/PD-L1 antibodies and STAT3 inhibitors might be a promising therapeutic approach for NKTL, and possibly PTCL.