Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

著者: Pierre Vantourout, Adam Laing, Martin J. Woodward, Iva Zlatareva, Luis Apolonia, Andrew W. Jones, Ambrosius P. Snijders, Michael H. Malim, Adrian Hayday - Proceedings of the National Academy of Sciences, PNAS 2018 被引用: 165

Significance Although gamma delta (γδ) T cells compose an evolutionarily conserved third lineage of diversified lymphocytes, alongside αβ T cells and B cells, they can seem overtly different across species and tissues. Thus, human blood γδ cells show butyrophilin (BTN)3A1-dependent responses to metabolites (“phosphoantigens”) not seen by rodent γδ cells, whereas some rodent, γδ-rich compartments, notably in the skin, lack obvious human counterparts. Recently, however, mouse and human intraepithelial gut γδ cells were found to be regulated by pairings of BTN-like genes. This study now shows that BTN3A1 also functions as a pairing, with its subcellular trafficking and optimal activity both regulated by BTN3A2. Hence, seemingly diverse γδ cell biologies across species and tissues are underpinned by conserved mechanisms.