Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors

著者: Carolyn M. Nielsen, Ane Ogbe, Isabela Pedroza‐Pacheco, Susanne E. Doeleman, Yue Chen, Sarah E. Silk, Jordan R. Barrett, Sean C. Elias, Kazutoyo Miura, Ababacar Diouf, Martino Bardelli, Rebecca A. Dabbs, Lea Barfod, Carole A. Long, Barton F. Haynes, Ruth Payne, Angela M. Minassian, Todd Bradley, Simon J. Draper, Persephone Borrow - Cell Reports Medicine 2021 被引用: 62

as compared to a Th1/Tfh1 skew with viral vectors. These data highlight the impact of vaccine platform on the cTfh cell response driving humoral immunity, associating a high-magnitude, Th2-biased cTfh response with potent antibody production.