Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort

著者: Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi, Tanayott Thaweethai, Peter Chen, Nathan Erdmann, Jason D. Goldman, Timothy J. Henrich, Mady Hornig, Elizabeth W. Karlson, Stuart D. Katz, Chun Kim, Sushma K. Cribbs, Adeyinka O. Laiyemo, Rebecca Letts, Janet Lin, Jai Marathe, Sairam Parthasarathy, Thomas F. Patterson, Brittany D. Taylor, Elizabeth R. Duffy, Monika Haack, Boris Jülg, Gabrielle Maranga, Carla Hernandez, Nora G. Singer, Jenny E. Han, Priscilla Pemu, Hassan Brim, Hassan Ashktorab, Alexander W. Charney, Juan P. Wisnivesky, Jenny J. Lin, Helen Y. Chu, Minjoung Go, Upinder Singh, Emily B. Levitan, Paul Goepfert, Janko Ž. Nikolich, Harvey Hsu, Michael J. Peluso, J. Daniel Kelly, Megumi J. Okumura, Valerie J. Flaherman, John G. Quigley, Jerry A. Krishnan, Mary Beth Scholand, Rachel Hess, Torri D. Metz, Maged M. Costantine, Dwight J. Rouse, Barbara S. Taylor, Mark P. Goldberg, Gailen D. Marshall, Jeremy P. Wood, David E. Warren, Leora Horwitz, Andrea S. Foulkes, Grace A. McComsey, RECOVER-Adult Cohort, Jeffrey Burns, Serena Spudich, L. Charles Bailey, Mine Cicek, Melissa Cortez, Felicia Davis Blakley, Andrea S. Foulkes, David C. Goff, Stuart D. Katz, Jessica Lasky‐Su, Torri Metz, Lisa T. Newman, Igho Ofotokun, Sudha Seshadri, Melissa Stockwell, James R. Stone, Brittany D. Taylor, PJ Utz, Neely Williams, Hassan Ashktorab, Jeannette M. Beasley, Karyn Bishof, Yu Chen, Lori B. Chibnik, Dani Dumitriu, Jennifer Frontera, Paul Goepfert, Sylvie Goldman, Stephen M. Hewitt, Matthew J. Huentelman, Barbara I. Karp, Jerry A. Krishnan, Sarah Laury, Bruce D. Levy, Janko Nikolich-Zugich, Margaret J. Ochocinska, Laura Pace, Alice Perlowski, William Reeves, Juan C. Salazar, Lumy Sawaki-Adams, Sujata Thawani, Hannah Valantine, Drenna Waldrop, Dana Wolff-Hughes, Marta Cerda, Victor H. Clash, Felicia Davis Blakley, Brittany Taylor, Mike Zissis, Teresa Akintonwa, Frank Blancero, Heather-Elizabeth Brown, Megan Carmilani, Debra Copeland, Yvonka Hall, kevin kondo, Lydia Lerma, Jacqui Lindsay, Heather Marti, Christine Maughan, Tony Minor, Hyatt Vincent, Andra L. Blomkalns, David Warburton, Ingrid V. Bassett, Rebecca G. Clifton, Hannah Davis, Nathan Erdmann, Valerie Flaherman, Margot Gage Witvliet, Mark P. Goldberg, Zoe Guan, Jonathan D. Klein, Gregory Laynor, Thomas F. Martínez, Rebecca McGrath, Sairam Parthasarathy, Priscilla Pemu, Erika B. Rosenzweig, Jacqueline Rutter, Hugh Auchincloss, Diana W. Bianchi, Jennifer Moss Breen, Patti Brennan, Jeffrey Burns, Nakela L. Cook, Felicia Davis Blakley, Betty Diamond, Mitchell S.V. Elkind, Lee Fleisher, Andrea Foulkes, Gary H. Gibbons, Laurie Gutmann, Michael F. Iademarco, Stuart Katz, Walter J. Koroshetz, Eldrin F. Lewis, Peter Marks, Hilary D. Marston, Mitchell G. Miglis, Lisa A. Newman, Tracy L. Nolen, Carlos A. Pardo, Amy Patterson, Samuel F. Posner, Wendy S. Post, Serena Spudich, Clinton B. Wright, Heather E. Yates, Kanecia O. Zimmerman, Gabriel Anaya, Audie A. Atienza, L. Charles Bailey, R. Graham Barr, Lisa G. Berdan, Andra L. Blomkalns, Melissa L. Bondy, Hassan Brim, Jeffrey Burns, Alexander W. Charney, Benjamin K. Chen, Mine Cicek, John F. Crary, Dawood Darbar, Kathi Diviak, Ray F. Ebert, Jamie Elifritz, Robert L. Ferrer, Josh Fessel, Aloke V. Finn, Thomas J. Flotte, Paul Fontelo, Andrea Foulkes, Emily J. Gallagher, Maria Gennaro, Mary Groesch, Rachel S. Gross, Melissa Haendel, James R. Heath, Rachel Hess, Stephen M. Hewitt, Sally Hodder, Carol R. Horowitz, Leora Horwitz, Vanessa L. Jacoby, Sarah E. Jolley, Suzanne E. Judd, Bill G. Kapogiannis, Elizabeth Karlson, Barbara I. Karp, Stuart Katz, Rainu Kaushal, Lawrence C. Kleinman, Jerry A. Krishnan, Sweta Ladwa, Craig Lefebvre, Lei Lei, Emily B. Levitan, Bruce D. Levy, Daniel Liu, Jeffrey N. Martin, Grace A. McComsey, Robin J. Mermelstein, Torri Metz, Lucio Miele, Sindhu Mohandas, Janet Mullington, Shawn Murphy, Jane W. Newburger, Lisa Newman, Margaret J. Ochocinska, Igho Ofotokun, Princess U. Ogbogu, Michelle Olive, Sairam Parthasarathy, Amy Patterson, Thomas Patterson, Gail D. Pearson, Priscilla Pemu, J. Zachary Porterfield, Antonello Punturieri, R. Ross Reichard, Jane E.B. Reusch, Kyung E. Rhee, Kathleen Rodgers, Juan C. Salazar, Amy Salisbury, Lumy Sawaki-Adams, Lisa Schwartz-Longacre, Sudha Seshadri, Howard D. Sesso, Eyal Shemesh, Allan C. Shipp, Upinder Singh, Jessica Snowden, Serena Spudich, Melissa Stockwell, James R. Stone, Jun Sun, Mehul S. Suthar, David M. Systrom, Brittany D. Taylor, Stephen N. Thibodeau, Andrea Troxel, PJ Utz, Tiffany Walker, David Warburton, Gail Weinmann, Neely Williams, Dana Wolff-Hughes, John C. Wood, Khamal Anglin, Emilia Bagiella, Ryan C. Branski, Rodica Pop‐Busui, Marissa Diggs, Vivian S. Gainer, Sunanda Gaur, Linda N. Geng, Sarah E. Jolley, Sarah Laury, Jai Marathe, Lisa McCorkell, Jarrod Mosier, Binita Shah, Dimpy P. Shah, Tiffany Walker, Peter Whitesell, Natasha Altman, Tellen D. Bennett, Soham Dasgupta, Marissa Edminston, Tyler Gustafson, Francois Haddad, Jennifer Hossain, Priscilla Hsue, Pavitra Kotini-Shah, Krishnan Sankaran, Anu Lala-Trindade, Simon Lee, Alem Mehari, Patricio Millar Vernetti, André L. Moreira, Anoop M. Nambiar, Robert F. Padera, Gail D. Pearson, Dhaval Raval, Franz Rischard, Erika B. Rosenzweig, Barbara A. Sampson, Frank C. Sciurba, Jackie Szmuszkovicz, Julie M. Thompson, Dongngan T. Truong, Viola Vaccarino, George Washko, John C. Wood, Hector Bonilla, Christine A. Capone, Sekai Chideya-Chihota, Dane B. Cook, Monica Gutierrez, Rohan Hazra, Leonard A. Jason, Phillip Joseph, Dan Kelly, Joyce Lee-Ianotti, Vincent C. Marconi, Joshua D. Milner, Benjamin H. Natelson, Lisa O’Brien, Carlos R. Oliveira, J. Zachary Porterfield, Claire Quiner, Zaki Sherif, Nora Singer, Inderjit Singh, David M. Systrom, Chen Sabrina Tan, Emily Taylor, Vanessa Thornburg, Suzanne D. Vernon, Quinn Barnette, Frank Blanceró, Mine Cicek, Lauren A. Decker, Jasmin Divers, Ray F. Ebert, Tonya Farris, Valerie Flaherman, Thomas J. Flotte, Andrea Foulkes, Rachel Gross, Sally Hodder, Leora I. Horwitz, Elizabeth Karlson, Stuart D. Katz, Craig Lefebvre, Lei Lei, Shawn N. Murphy, Lisa Newman, Michelle Olive, Tony Punturieri, Lisa Schwartz Longacre, Upinder Singh, Stephen N. Thibodeau, Andrea B. Troxel, David Warburton, Jordan C. Weyer, Brett R. Anderson, Sujata Bardhan, Leah Castro-Baucom, Deena J. Chisolm, Alicia Chung, Claudia Corchado, Casey L. Daniel, Walter Dehority, Gniesha Y. Dinwiddie, Candace H. Feldman, Lisa G. Rosas, Carol R. Horowitz, Janice John, Gelise L. Thomas, Keila N. Lopez, Karen Lutrick, Carina Marquez, Shelly McDonald Pinkett, Lidia Regino, Kim F. Rhoads, Sarah Stewart de Ramirez, Joel Tsevat, Carlos Valencia, Nita Vangeepuram, Anita Walden, Zanthia Wiley, Neely Williams, H. Shonna Yin, Galit Alter, Hulya Bukulmez, Chao Jiang, Ai‐ris Y. Collier, Karen H. Costenbader, Betty Diamond, Rao L. Divi, Nahed El Kassar, Nathan Erdmann, F. Eun‐Hyung Lee, Alicia Gaffney, Sacha Gnjatic, Jason Goldman, Jim F. Heath, Jennifer Hossain, Hye-Sook Kim, Ellen Kraig, Timothy Lewis, Joy Liu, Gabrielle Maranga, Aprajita Mattoo, Joshua D. Milner, Sindhu Mohandas, Janko Nikolich-Zugich, Princess U. Ogbogu, Michael J. Peluso, Bellur S. Prabhakar, Jay S. Raval, Mark Sullivan, Paul J. Thuluvath, PJ Utz, Sidney W. Whiteheart, Nina Caplin, Dawood Darbar, Katie Fain, Thomas J. Flotte, David S. Goldstein, Meredith Hay, Ellie Hirshberg, Barbara I. Karp, Dean L. Kellogg, Rebecca Letts, Meisha Mandal, Janet Mullington, Michael Portman, David Putrino, Jacqueline Rutter, Lumy Sawaki-Adams, Joel D. Trinity, John C. Wood, Roham T. Zamanian, Judy Aberg, Farshad Aduli, Andrew M. Atz, Lawrence Baizer, Hector Bonilla, Patricia Ceger, Maged M. Costantine, Amelia N. Deitchman, Kelly K. Filipski, Jeffrey Fine, Liza Fisher, Paul Fontelo, Vilma Gabbay, Jason D. Goldman, Mi Hillefors, Verna Holmes, Arthur Y. Kim, Grace McComsey, Grégory Mertz, Sindhu Mohandas, Margaret Ochinska, Thomas F. Patterson, Michael J. Peluso, John G. Quigley, Kathleen Rodgers, Nadine Rouphael, Gwen Shaw, Bob Tamburro, David Williams, William T. Zempsky, Christian Bime, Steven B. Bradfute, Benjamin K. Chen, Tom Connors, Krista Coombs, Glenn I. Fishman, Maria Gennaro, Christian R. Gómez, Timothy J. Henrich, David Hines, Prasanna Jagganathan, Judith A. James, Kevin Jordan, Boris Juelg, Christina Kim, Jia Lu, Sindhu Mohandas, Michael Portman, Erin Burke Quinlan, Brian Reeves, Jalees Rehman, Ignacio Sanz, Zaki Sherif, Guofei Zhou, Irina A. Buhimschi, Floyd H. Chilton, Ralph A. DeFronzo, Emily J. Gallagher, Jennifer Hossain, Wendy Jefferson, Mandana Khalili, Angesom Kibreab, Tracey McLaughlin, Nandini Nair, Venkat Narayan, Elizabeth Phillips Lorenzo, Jane E.B. Reusch, Ivonne Hernandez Schulman, Aasma Shaukat, Deborah J. Wexler, Jonah Zaretsky, William Alexander, Leyna Aragon, Ami S. Bhatt, Hassan Brim, Shari B. Brosnahan, John M. Coffin, Adolfo García‐Sastre, Maria Laura Gennaro, Joerg Graf, Timothy Henrich, Nahed Ismail, Paul Keim, Hye-Sook Kim, Jeanne Marrazzo, Rebecca McGrath, Sindhu Mohandas, Christopher Montgomery, Radu Postelincu, Ryan T. Ranallo, Kentner Singleton, Adam M. Spivak, Mehul S. Suthar, Mary Thomas, Guangming Zhong, John Andrefsky, Bryan Bander, J. Douglas Bremner, Michael D. Carrithers, Melissa Cortez, Richard Gallagher, Joanna Hellmuth, Tammy Kershner, Mansoor Malik, Shawn Murphy, Ganesh Murthy, Sharon O’Neil, Lisa Prentiss, Caitlin Rollins, Jonathan Rosand, Scott J. Russo, Amy Salisbury, Alan C. Seifert, Sudha Seshadri, Eyal Shemesh, Wendy G. Silver, Naomi M. Simon, Leanne E. Williams, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Jasmin Divers, Mike Enger, Stephen Erickson, Joaquı́n M. Espinosa, Xiaowu Gai, Stephen M. Hewitt, Benjamin D. Horne, Paul Keim, Jessica Lasky‐Su, Cheryl L. Maier, Meisha Mandal, Lucio Miele, Emmanuel F. Mongodin, Lauren Nichols, Nadia R. Roan, Mark W. Russell, George R. Saade, Kumar Sharma, Stephanie Shiau, Jun Sun, Stephen N. Thibodeau, Sam Yang, Nina Blachman, Natalie Boutin, Phoebe Burton, Marina Catallozzi, Cheryl R. Clark, Beth Dworetzky, Belinda Edwards, Robert L. Ferrer, Catherine Freeland, Beatrice Huang, Suzanne E. Judd, Sarah Laury, Hugh Musick, Divya Pathak, Kristen Pogreba-Brown, Hengameh Raissy, Lynne Richardson, Russell L. Rothman, Laura Wagner, Ann Wallace, Stephanie Archer, Paul Barach, Melissa L. Bondy, Víctor M. Castro, Mine Cicek, Joanne W. Elena, Kacey C. Ernst, Josh Fessel, Daniel Fort, Brian Hendricks, Bertha Hidalgo, Cory Hussain, Carmen R. Isasi, Dan Kelly, Adeyinka O. Laiyemo, Margaret Lanca, Juan Lewis, Beth Linas, Heidi T. May, Kimberly E. McHugh, Naoko Muramatsu, Girish N. Nadkarni, Susan Nance, Kian Nguyen, Priscilla Pemu, Lisa Postow, Suchitra Rao, Dimpy P. Shah, Sidd Shenoy, Kendall Tosco, Dana L. Wolff‐Hughes, C. M. Bailey, James Chan, Nancy Chang, Mine S. Cicek, Hannah Davis, Kathi Diviak, Daniel Fort, Jennifer C. Gander, Janos Hajagos, Kellie L. Hawkins, Md Shahidul Islam, Dan Kelly, Tammy Kershner, Patricia Kovatch, Simon Li, Daniel Liu, Holden T. Maecker, F Mahmood, Emily Pfaff, Anisha Sekar, Zaki A. Sherif, Vignesh Subbian, M. Thakrar, Anand Viswanathan, Jennifer L. Wheeler, Meredith Zozus, Yvette Burgos, Chris Chute, Elizabeth W. Karlson, Barbara I. Karp, Emily B. Levitan, Gabrielle Maranga, Gailen D. Marshall, Jeffrey N. Martin, Robin Mermelstein, Torri D. Metz, Igho Ofotokun, Sairam Parthasarathy, Lumy Sawaki-Adams, Mary Beth Scholand, Howard D. Sesso, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Juan P. Wisnivesky, Lisa T. Newman, Julie Abella, Quinn Barnette, Christine A. 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Gallini, Evan Gutter, Jess Harding, Lisa Harewood, Liliana Hernández, Carla Holloway, Cynthia Ifejika, Kelechi Igwe, Rijalda Jasarevic, Vidhi Javia, Mykayla Jeter, Yasha Joseph, Monica Juarez, Caitlin M. Kirkpatrick, Athena Koumanelis, Rebecca Kozoman, Shilpa Krishnan, Jordi Lainez, Jose D. Leon, Valerie Lew, Kelly Mahfood, Cheryl L. Maier, Nour Makkaoui, Mara Maroney, Christopher F. Martin, Loice Mbogo, Atuarra McCaslin, J. McIntyre, Abeer Moanna, Miranda Montoya, Elena Martín Morales, Caitlin A. Moran, Calista Murray, Roslin Nelson, Tran Thuy Nguyen, B. Ojoawo, Eileen Osinski, Sofia Oviedo, Yolanda Paredes-Gaitan, Michael Prude, Grace Ramakrishnan, Paulina A. Rebolledo, Marjorie Roberts, Keysha Robinson, Chantrice Rogers, Nadine Rouphael, Charles Searles, Marni Segall, Anand Shah, Renata Michelle Shaw, Ruvina Silva, Cheryl Simpson, Krystal Simpson-Derrell, Talib Sirajud-Deen, Jacob Stroud, Mehul S. Suthar, Cory Sylber, Ashley Sylvera, Tehquin Tanner, Larissa Teunis, Kodasha M. Thomas, Kehmia Titanji, Christopher Toy, Alex Truong, Viola Vaccarino, Kris Varney, Kartavya J. Vyas, Kurt Vyas, Max Walkow, Tamara Wesley, Juton R. Winston, Terra J. Winter, Cherry Wongtrakool, Zanthia Wiley, Arijan Ager, Mary Atha, Rebecca Fineman, Natalie Gray, Ash Grimes, Lauren N. Hewitt, Christopher Huerta, Brandi Johnson, Lana Khalil, Dean J. Kleinhenz, Alexandra Koumanelis, Matthew A. Lee, Kennedy C. Lewis, Matthew Litvack, Bernadine Panganiban, Kazi Mizanur Rahman, Veronica E. Smith, Andre Stringer, Maliya Tolbert, Jessica Traenkner, Kristen Unterberger, Dongli Wang, Erika Wimberly, Priscilla Pemu, Annette Dandy, Carmel Ibeawuchi, Dana Kajan, Brianna Lawrence, Jan Morgan‐Billingslea, Elizabeth I. Ojemakinde, Elizabeth Olorundare, Sushma K. Cribbs, Anyssa G. Francis, Tina P. Hang, Ketteria D. Ingram, Jennifer C. Gander, Robert B. Neuman, Patricia A. Bush, Alex F. Hudgins, Imanii Kolailat, Monica Martinez, Sierra G. Thompson, Bruce D. Levy, Robert F. Padera, Masanori Aikawa, David C. Alsop, Rachel Atchley-Challenner, Lindsey R. Baden, Gaston Baslet, Shamik Bhattacharyya, Renee Brody, Julie E. Buring, R. Cagnina, Long‐Qing Chen, Cheryl R. Clark, Pieter A. Cohen, Andrea M. Collins, Charles A. Czeisler, Sourbha S. Dani, Candace H. Feldman, Sarju Ganatra, Elizabeth Gay, Sheila M. Hegde, Elizabeth W. Karlson, Matcheri S. Keshavan, Marvin A. Konstam, Daniela Lamas, Elizabeth LaSalvia, Jessica Lasky‐Su, Nomi C. Levy‐Carrick, Chun Soo Lim, JoAnn E. Manson, Edward Mercantonio, Murray A. Mittleman, Debra D. Poutsiaka, Susan Redline, Howard D. Sesso, Michelle Siciliano, Isaac H. Solomon, Scott D. Solomon, Jeffrey A. Sparks, Jennifer L. Stevens, Paul Summergrad, David M. Systrom, Andrew J. Taylor, David S. Thaler, David R. Walt, George Washko, Ingrid V. Bassett, Shawn N. Murphy, James R. Stone, George A. Alba, Taing N. Aung, Faye Victoria C. Casimero, Leo C. Ginns, Jennifer S. Haas, Boris D. Juelg, Diane G. Kanjilal, Arthur Y. 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Daniel Brooks, Etienne Carignan, Megan Carmilani, Leah Castro-Baucom, Marta Cerda, Krista Coombs, Debra Copeland, Claudia Corchado, Hannah Davis, Felicia Davis Blakley, Marissa Diggs, Belinda Edwards, Heather E. Brown, Umar Favors, Whitney Fields, Liza Fisher, Megan Fitzgerald, Margot Gage Witvliet, Roberto García, Tyler Gustafson, Nick Güthe, Yvonka Hall, Verna Holmes, Mady Hornig, Maxwell Hornig, Wendy Jefferson, Christina Kim, Nancy Kochis, kevin kondo, Julie A. Lam, Fadwa Lawrence, Lydia Lerma, Rebecca Letts, Juan Lewis, Jacqui Lindsay, Silcia Lopez, Heather Marti, Thomas F. Martínez, Christine Maughan, Lisa McCorkell, Rebecca McGrath, Thomas T. Minor, Charita Moore, Kian Nguyen, Lauren Nichols, Lisa O’Brien, Holly Olson, Aimee Peddie, Elizabeth Phillips Lorenzo, Lisa Prentiss, Nadia Raytselis, Lidia Regino, Marjorie Roberts, Nitza Rochez, Megan Rockwell, Jacqueline Rutter, Nitza Rochez, Elle Seibert, Anisha Sekar, Chimere Smith, Lauren E. Stiles, Brittany Taylor, Emily Taylor, Julie M. Thompson, Stephen K. Trapp, Stephen Valdiva, Hyatt Vincent, Ann Wallace, R. Wilensky, Melissa Williams, Neely Williams, Kay W. Dawson, Andrew Wylam, Mike Zissis - Annals of Internal Medicine 2024 被引用: 45

BACKGROUND: There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC). OBJECTIVE: To investigate clinical laboratory markers of SARS-CoV-2 and PASC. DESIGN: Propensity score-weighted linear regression models were fitted to evaluate differences in mean laboratory measures by prior infection and PASC index (≥12 vs. 0). (ClinicalTrials.gov: NCT05172024). SETTING: 83 enrolling sites. PARTICIPANTS: RECOVER-Adult cohort participants with or without SARS-CoV-2 infection with a study visit and laboratory measures 6 months after the index date (or at enrollment if >6 months after the index date). Participants were excluded if the 6-month visit occurred within 30 days of reinfection. MEASUREMENTS: Participants completed questionnaires and standard clinical laboratory tests. RESULTS: levels was attenuated after participants with preexisting diabetes were excluded. Among participants with prior infection, no meaningful differences in mean laboratory values were found between those with a PASC index of 12 or higher and those with a PASC index of zero. LIMITATION: Whether differences in laboratory markers represent consequences of or risk factors for SARS-CoV-2 infection could not be determined. CONCLUSION: Overall, no evidence was found that any of the 25 routine clinical laboratory values assessed in this study could serve as a clinically useful biomarker of PASC. PRIMARY FUNDING SOURCE: National Institutes of Health.