Protective role of berberine on ulcerative colitis through modulating enteric glial cells–intestinal epithelial cells–immune cells interactions

著者: Heng Li, Chen Fan, Huimin Lu, Chunlan Feng, Pei‐Lan He, Xiaoqian Yang, Caigui Xiang, Jianping Zuo, Wei Tang - Acta Pharmaceutica Sinica B 2019 被引用: 216

, berberine showed direct protective effects on monoculture of EGCs, bone marrow-derived dendritic cells (BMDCs), T cells, and intestinal epithelial cells (IECs) in the simulated inflammatory conditions. Furthermore, berberine could modulate gut EGCs-IECs-immune cell interactions in the co-culture systems. In summary, our study indicated the EGCs-IECs-immune cell interactions might function as a crucial paradigm in mucosal inflammation and provided an infusive mechanism of berberine in regulating enteric neurogenic inflammation.