Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD

著者: D. Parker Kelley, Katy Venable, Aspasia Destouni, Gerald Billac, Philip J. Ebenezer, Krisztián Stadler, Charles D. Nichols, Steven A. Barker, Joseph Francis - ACS Chemical Neuroscience 2022 被引用: 41

R compared to 5-HT. DMT and pharmahuasca reduced ROS production in the PFC and HC, while harmaline had mixed effects. Treatments normalized 9, 12, and 14 overlapping DEGs, and pathway analysis implicated that genes were involved in ROS production, inflammation, growth factor signaling, neurotransmission, and neuroplasticity.