Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

著者: Yuying Liu, Yiliang Fang, Xinfeng Chen, Zhenfeng Wang, Xiaoyu Liang, Tianzhen Zhang, Mengyu Liu, Nannan Zhou, Jiadi Lv, Ke Tang, Jing Xie, Yunfeng Gao, Feiran Cheng, Yabo Zhou, Zhen Zhang, Yu Hu, Xiaohui Zhang, Quanli Gao, Yi Zhang, Bo Huang - Science Immunology 2020 被引用: 547

GSDME-mediated target cell pyroptosis by CAR T cells activates macrophages to release proinflammatory cytokines for CRS.