The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

著者: Robert C. Reiner, LBD Triple Burden Collaborators, Catherine A. Welgan, Christopher Troeger, Mathew M Baumann, Daniel J. Weiss, Aniruddha Deshpande, Brigette F. Blacker, Molly K. Miller-Petrie, Lucas Earl, Samir Bhatt, Hassan Abolhassani, Akine Eshete Abosetugn, Eman Abu‐Gharbieh, Victor Adekanmbi, Olatunji Adetokunboh, Mohammad Aghaali, Budi Aji, Fares Alahdab, Ziyad Al‐Aly, Robert Kaba Alhassan, Saqib Ali, Hesam Alizade, Syed Mohamed Aljunid, Amir Almasi‐Hashiani, Hesham M. Al‐Mekhlafi, Khalid A Altirkawi, Nelson Alvis‐Guzmán, Azmeraw T. Amare, Saeed Amini, Dickson A Amugsi, Robert Ancuceanu, Cătălina Liliana Andrei, Fereshteh Ansari, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Olatunde Aremu, Maha Atout, Marcel Ausloos, Floriane Ausloos, Martin Amogre Ayanore, Yared Asmare Aynalem, Zelalem Nigussie Azene, Alaa Badawi, Atif Amin Baig, Maciej Banach, Neeraj Bedi, Akshaya Srikanth Bhagavathula, Dinesh Bhandari, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Zulfiqar A Bhutta, Ali Bijani, Tesega Tesega Mengistu Birhanu, Zebenay Workneh Bitew, Archith Boloor, Oliver J. Brady, Zahid A Butt, Josip Car, Félix Carvalho, Daniel Casey, Vijay Kumar Chattu, Mohiuddin Ahsanul Kabir Chowdhury, Dinh‐Toi Chu, Camila H. Coelho, Aubrey J. Cook, Giovanni Damiani, Farah Daoud, Jiregna Darega Gela, Amira Hamed Darwish, Ahmad Daryani, Jai K Das, Nicole Davis Weaver, Kebede Deribe, Assefa Desalew, Samath Dhamminda Dharmaratne, Mostafa Dianatinasab, Daniel Díaz, Shirin Djalalinia, Fariba Dorostkar, Eleonora Dubljanin, Bereket Duko, Laura Dwyer‐Lindgren, Andem Effiong, Maysaa El Sayed Zaki, Maha El Tantawi, Shymaa Enany, Nazir Fattahi, Valery L. Feigin, Eduarda Fernandes, Pietro Ferrara, Florian Fischer, Nataliya A Foigt, Morẹ́nikẹ́ Oluwátóyìn Foláyan, Masoud Foroutan, Joseph Frostad, Takeshi Fukumoto, Abhay Gaidhane, Hailemikael Gebrekidan G. K. Gebrekrstos, Leake Gebremeskel, Assefa Ayalew Gebreslassie, Peter W. Gething, Kebede Embaye Gezae, Keyghobad Ghadiri, Ahmad Ghashghaee, Mahaveer Golechha, Mohammed Ibrahim Mohialdeen Gubari, Fikaden Berhe Hadgu, Samer Hamidi, Demelash Woldeyohannes Handiso, Abdiwahab Hashi, Shoaib Hassan, Khezar Hayat, Claudiu Herţeliu, Hung Chak Ho, Ramesh Holla, Mehdi Hosseinzadeh, Mowafa Househ, Rabia Hussain, Bing‐Fang Hwang, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena Ilić, Milena Ilić, Seyed Sina Naghibi Irvani, Jalil Jaafari, Tahereh Javaheri, Ravi Prakash Jha, Kimberly B. Johnson, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Rohollah Kalhor, Tanuj Kanchan, André Karch, Gbenga A Kayode, Peter Njenga Keiyoro, Yousef Khader, Ibrahim A. Khalil, Md Nuruzzaman Khan, Maseer Khan, Gulfaraz Khan, Khaled Khatab, Mona M Khater, Mahalaqua Nazli Khatib, Neda Kianipour, Yun Jin Kim, Ruth W Kimokoti, Sezer Kısa, Adnan Kısa, Niranjan Kissoon, Sonali Kochhar, Ali Koolivand, Jacek A Kopec, Ai Koyanagi, Kewal Krishan, Pushpendra Kumar, Om Kurmi, Dian Kusuma, Dharmesh Kumar Lal, Faris Hasan Lami, Iván Landires, Van Charles Lansingh, Savita Lasrado, Carlo La Vecchia, Alice Lazzar-Atwood, Paul H. Lee, Kate E LeGrand, Sonia Lewycka, Bingyu Li, Stephen S Lim, Paulina A Lindstedt, Xuefeng Liu, Joshua Longbottom, Alan D Lopez, Hassan Magdy Abd El Razek, Phetole Walter Mahasha, Afshin Maleki, Abdullah Al Mamun, Mohammad Alì Mansournia, Laurie B. Marczak, Francisco Rogerlândio Martins‐Melo, Benjamin K. Mayala, Birhanu Geta Meharie, Addisu Melese, Walter Mendoza, Ritesh G. Menezes, Endalkachew Worku Mengesha, George A. Mensah, Tuomo J Meretoja, Tomislav Meštrović, Ted R. Miller, Erkin М Мirrakhimov, Babak Moazen, Naser Mohammad Gholi Mezerji, Shadieh Mohammadi, Shafiu Mohammed, Ali H. Mokdad, Masoud Moradi, Rahmatollah Moradzadeh, Paula Moraga, Jonathan F Mosser, Chrisopher J. L. Murray, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Javad Nazari, Rawlance Ndejjo, Ionuţ Negoi, Josephine W Ngunjiri, QuynhAnh P Nguyen, Huong Lan Thi Nguyen, Chukwudi A Nnaji, Jean Jacques Noubiap, Virginia Núñez-Samudio, Andrew T Olagunju, Jacob Olusegun Olusanya, Bolajoko O. Olusanya, Muktar Omer Omer, Obinna Onwujekwe, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa Owolabi, P A Mahesh, Jagadish Rao Padubidri, Adrian Pană, Emmanuel Peprah, Hai Quang Pham, David M. Pigott, Majid Pirestani, Maarten J. Postma, Faheem Hyder Pottoo, Hadi Pourjafar, Zahiruddin Quazi Syed, Fakher Rahim, Vafa Rahimi‐Movaghar, Mohammad Hifz Ur Rahman, Sowmya J Rao, Puja C Rao, Priya Rathi, Salman Rawaf, David Laith Rawaf, Lal Rawal, Reza Rawassizadeh, Lemma Demissie Regassa, André M. N. Renzaho, Nima Rezaei, Mohammad Sadegh Rezai, Ana Isabel Ribeiro, Jennifer Rickard, Carlos Miguel Ríos-González, Susan F. Rumisha, Siamak Sabour, S. Mohammad Sajadi, Joshua A. Salomon, Hossein Samadi Kafil, Abdallah M Samy, Juan Sanabria, Benn Sartorius, Deepak Saxena, Lauren E. Schaeffer, Subramanian Senthilkumaran, Feng Sha, Amira Shaheen, Masood Ali Shaikh, Rajesh Sharma, Aziz Sheikh, Kenji Shibuya, Mika Shigematsu, Jae Il Shin, Biagio Simonetti, Jasvinder A. Singh, David L. Smith, Amin Soheili, Anton Sokhan, Emma Elizabeth Spurlock, Chandrashekhar T Sreeramareddy, Mu’awiyyah Babale Sufiyan, Scott J. Swartz, Degena Bahrey Tadesse, Animut Tagele Tamiru, Yonas Getaye Tefera, Mohamad‐Hani Temsah, Zemenu Tadesse Tessema, М. В. Титова, Bach Xuan Tran, Phuong N. Truong, Bhaskaran Unnikrishnan, Era Upadhyay, Tommi Vasankari, Yasser Vasseghian, Francesco Saverio Violante, Giang Thu Vu, Yasir Waheed, Richard G. Wamai, Emebet Gashaw Wassie, Fissaha Tekulu Welay, Nuwan Darshana Wickramasinghe, Kirsten E. Wiens, Tissa Wijeratne, Charles Shey Wiysonge, Temesgen Gebeyehu Wondmeneh, Tomohide Yamada, Sanni Yaya, Yordanos Gizachew Yeshitila, Paul Yip, Naohiro Yonemoto, Chuanhua Yu, Deniz Yüce, Hasan Yusefzadeh, Zoubida Zaidi, Maryam Zamanian, Alireza Zangeneh, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Simon I Hay - Nature Communications 2022 被引用: 28

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.