Bacterial Epidemiology and Antimicrobial Resistance Profiles in Children Reported by the ISPED Program in China, 2016 to 2020

著者: Pan Fu, Hongmei Xu, Chunmei Jing, Jikui Deng, Hongmei Wang, Chunzhen Hua, Yinghu Chen, Xuejun Chen, Ting Zhang, Hong Zhang, Yiping Chen, Jinhong Yang, Aiwei Lin, Shifu Wang, Qing Cao, Xing Wang, Huiling Deng, Sancheng Cao, Jianhua Hao, Wei Gao, Yuanyuan Huang, Hui Yu, Chuanqing Wang - Microbiology Spectrum 2021 被引用: 101

AMR, especially that involving multidrug-resistant organisms (MDROs), is recognized as a global threat to human health; AMR renders infections increasingly difficult to treat, constituting an enormous economic burden and producing tremendous negative impacts on patient morbidity and mortality rates. There are many surveillance programs in the world to address AMR profiles and MDRO prevalence in humans. However, published studies evaluating the overall AMR rates or MDRO distributions in children are very limited or are of mixed quality. In this study, we showed the bacterial epidemiology and resistance profiles of primary pathogens in Chinese children from 2016 to 2020 for the first time, analyzed MDRO distributions with time and with age, and described MDROs' potential threats to children, especially low-immunity neonates. Our study will be very useful to guide antiinfection therapy in Chinese children, as well as worldwide pediatric patients.