Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade

著者: Thomas B. Huffaker, Soh-Hyun Lee, William W. Tang, Jared Wallace, Margaret Alexander, Marah C. Runtsch, Dane K. Larsen, Jacob Thompson, Andrew G. Ramstead, Warren P. Voth, Ruozhen Hu, June L. Round, Matthew A. Williams, Ryan M. O’Connell - Journal of Biological Chemistry 2017 被引用: 86

T cells, suggesting that miR-155 and ICB regulate overlapping pathways to promote antitumor immunity. Taken together, our findings highlight the multifaceted role of miR-155 in T cells, in which it promotes antitumor immunity. These results suggest that the augmentation of miR-155 expression could be used to improve anticancer immunotherapies.