Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

著者: Jichao Sun, Lina Wang, Huan Bao, Sanjay Premi, Utpal Das, Edwin R. Chapman, Subhojit Roy - Proceedings of the National Academy of Sciences, PNAS 2019 被引用: 206

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone-but with no effect on neurotransmission-while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.