Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study

著者: Maureen M. Leonard, Francesco Valitutti, Hiren Karathia, Meritxell Pujolassos, Victoria Kenyon, Brian Fanelli, Jacopo Troisi, Poorani Subramanian, Stephanie Camhi, Angelo Colucci, Gloria Serena, Salvatore Cucchiara, Chiara Maria Trovato, Basilio Malamisura, Ruggiero Francavilla, Luca Elli, Nur A. Hasan, Ali R. Zomorrodi, Rita R. Colwell, Alessio Fasano, The CD-GEMM Team, Monica Montuori, Pasqua Piemontese, Angela Calvi, Mariella Baldassarre, Lorenzo Norsa, Celeste Lidia Raguseo, Tiziana Passaro, Paola Roggero, Marco Crocco, Annalisa Morelli, Michela Perrone, Naire Sansotta, Marcello Chieppa, Giovanni Scala, Maria Elena Lionetti, Carlo Catassi, Adelaide Serretiello, C Vecchi, Gemma Castillejo de Villsante - Proceedings of the National Academy of Sciences, PNAS 2021 被引用: 157

Significance The incidence of chronic inflammatory autoimmune conditions, such as celiac disease (CD), is increasing at an alarming rate. CD is the only autoimmune condition for which the trigger, gluten, is known. However, its etiology and pathogenesis remain incompletely defined as recent studies suggest other environmental stimuli may play a key role in CD pathogenesis. Here, we prospectively examine the trajectory of the gut microbiota starting 18 mo before CD onset in 10 infants who developed CD and 10 infants who did not. We identified alterations in the gut microbiota, functional pathways, and metabolome before CD onset, suggesting our approach may be used for disease prediction with the ultimate goal of identifying early preventive interventions to reestablish tolerance and prevent autoimmunity.