sTREM-1 is a specific biomarker of TREM-1 pathway activation

著者: Lucie Jolly, Kévin Carrasco, Margarita Salcedo‐Magguilli, Jean–Jacques Garaud, Simon Lambden, Tom van der Poll, Alexandre Mebazaa, Pierre‐François Laterre, Sébastien Gibot, Amir Boufenzer, Marc Derive - Cellular and Molecular Immunology 2021 被引用: 75

TREM-1 (triggering receptor expressed on myeloid cells-1) is a transmembrane receptor expressed by innate immune cells, including endothelial cells and platelets. TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors (TLRs) to amplify the inflammatory responses to pathogens, thus promoting sepsis-induced immune dysregulation and organ dysfunction. [...]