ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

著者: Lena Ho, Marie van Dijk, Sam Tan Jian Chye, Daniel M. Messerschmidt, Serene C. Chng, Sheena L. M. Ong, Ling Yi, Souad Boussata, Grace H. Goh, Gijs Afink, Chin Yan Lim, N. Ray Dunn, Davor Solter, Barbara B. Knowles, Bruno Reversade - Science 2017 被引用: 215

Modeling a pregnancy disorder Preeclampsia, a dangerous pregnancy disorder marked by high blood pressure, can lead to premature birth and be life-threatening to the mother and baby. Research leading to effective treatments has been hampered by a lack of informative animal models. Ho et al. identified ELABELA as a hormone produced by the placenta whose levels are lower in preeclampsia (see the Perspective by Wirka and Quertermous). ELABELA-deficient pregnant mice showed clinical signs of preeclampsia, including high blood pressure and elevated urine protein. A proportion of embryos lacking ELABELA displayed defective heart development, and full-term pups had low birth weights. Science , this issue p. 707 ; see also p. 643