Metagenome Analysis of Bodily Microbiota in a Mouse Model of Alzheimer Disease Using Bacteria-derived Membrane Vesicles in Blood

著者: Jin Young Park, Juli Choi, Yunjin Lee, Jung-Eun Lee, Eun Hwa Lee, Hye-Jin Kwon, Jinho Yang, Bo-Ri Jeong, Yoon‐Keun Kim, Pyung‐Lim Han - Experimental Neurobiology 2017 被引用: 153

decreased in Tg-APP/PS1 mice. A number of genus members were detected in Tg-APP/PS1 mice, but not in wild-type mice, while other genus members were detected in wild-type mice, but lost in Tg-APP/PS1 mice. The results of the present study suggest that the bodily microbiota profile is altered in Tg-APP/PS1 mice, and that blood EVs are useful for the metagenome analysis of bodily microbiota in AD.