GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

著者: David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro‐Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez‐Carrera - Cell Reports 2021 被引用: 109

mice show reduced AMPK activation in skeletal muscle, whereas GDF15 administration results in AMPK activation in this organ. Collectively, these data reveal a mechanism by which PPARβ/δ activation increases GDF15 levels via AMPK and p53, which in turn mediates the metabolic effects of PPARβ/δ by sustaining AMPK activation.