The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

著者: Juan F. Linares, Tania Cid-Diaz, Ángeles Durán, Marta Osrodek, Anxo Martínez-Ordóñez, Miguel Reina‐Campos, Hui–Hsuan Kuo, Olivier Elemento, M L Collado Martín, Thekla Cordes, Timothy C. Thompson, Christian M. Metallo, Jorge Moscat, María T. Díaz‐Meco - Cell Reports 2022 被引用: 69

renders CAFs less active. PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity.