Cardiac and Coronary Prostaglandin Synthesis and Function
Prostaglandin and Thromboxane Metabolic Pathway — OverviewTHE prostaglandins (PG) are synthesized by virtually every tissue in the body.1 Their release can be stimulated by various means, including hormones (e.g., bradykinin and angiotensin II), nerve stimulation or exogenous neurotransmitters, mechanical damage and decreased oxygen tension.2 3 4 5 6 7 8 9 Since there is no evidence for storage of prostaglandins, release reflects de novo biosynthesis.9 , 10 Little, if any, prostaglandin is detected in arterial blood, largely because of efficient pulmonary destruction3 , 9; thus, prostaglandins should be considered local hormones that are synthesized at or near their site of action.Prostaglandins are formed by the enzymatic oxygenation of . . .