PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

著者: Mafalda Almeida, Greta Pintacuda, Osamu Masui, Yoko Koseki, Michał R. Gdula, Andrea Cerase, David T. Brown, Arne W. Mould, Cassandravictoria Innocent, Manabu Nakayama, Lothar Schermelleh, Tatyana B. Nesterova, Haruhiko Koseki, Neil Brockdorff - Science 2017 被引用: 290

Polycomb steps to inactivate X XX females silence one of their X chromosomes. This involves a process whereby a noncoding RNA known as Xist coats one of the X chromosomes and recruits chromatin silencing factors. The Polycomb complexes PRC1 and PRC2 are also known to be involved in X chromosome inactivation. Almeida et al. elucidate a key role of a specific complex, PCGF3/5-PRC1, in initiating Polycomb recruitment by Xist RNA. They further demonstrate that Polycomb recruitment is critical for Xist-mediated chromosome silencing and female embryogenesis. Science , this issue p. 1081