Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma

著者: John Choi, Ravi Medikonda, Laura Saleh, Timothy Kim, Ayush Pant, Siddhartha Srivastava, Young‐Hoon Kim, Christina Jackson, Luqing Tong, Denis Routkevitch, Christopher M. Jackson, Dimitrios Mathios, Tianna Zhao, Hyerim Cho, Henry Brem, Michael Lim - OncoImmunology 2021 被引用: 48

= .0136). This is the first preclinical investigation into the effects of combination checkpoint blockade with anti-PD-1 and anti-BTLA treatment in GBM. We also show a direct effect on activated immune cell populations such as CD4+ and CD8 + T cells and immunosuppressive regulatory T cells through this combination therapy.