Genome-wide minor histocompatibility matching as related to the risk of graft-versus-host disease

著者: Paul J. Martin, David Levine, Barry E. Storer, Edus H. Warren, Xiuwen Zheng, Sarah C. Nelson, Anajane G. Smith, Bo Kok Mortensen, John A. Hansen - Blood 2016 被引用: 114

= .03). In HLA-A, B, C, DRB1, DQA1, DQB1, DPA1, DPB1-phenotypically matched unrelated recipients, the average recipient mismatching of coding SNPs was 17.3%. The estimated risks of GVHD-related outcomes in HLA-phenotypically matched unrelated recipients were low, relative to the large difference in genome-wide mismatching between the 2 groups. In contrast, the risks of GVHD-related outcomes were higher in HLA-DP GVH-mismatched unrelated recipients than in HLA-matched sibling recipients. Taken together, these results suggest that the increased GVHD risk after unrelated HCT is predominantly an effect of HLA-mismatching.