The role of LTBPs in TGF beta signaling

著者: Daniel B. Rifkin, Nalani Sachan, Karan Singh, Elyse Sauber, George Tellides, Francesco Ramirez - Developmental Dynamics 2021 被引用: 58

The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.