C-reactive protein as a prognostic indicator in COVID-19 patients

著者: Mahmoud Sadeghi Haddad Zavareh, Masomeh Bayani, Mehran Shokri, Soheil Ebrahimpour, Arefeh Babazadeh, Zahra Geraili, Emaddudin Moudi, Ali Rostami, Mohammad Barari, Akram sadat Hosseini, Ali Bijani, Mostafa Javanian - 2021 被引用: 22

Abstract While some biomolecules have been explored to identify potential biomarkers for prognosis of the COVID-19 prognosis, there are no reliable prognostic indicators of disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe cases (n = 175) and nonsevere cases (n = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of ROC curve found that CRP could be used as an independent factor in predicting the severity of COVID-19 infection. Also, patients with CRP > 64.75 mg/L were more likely to have severe complications. The serum levels of CRP can predict the severity and progression of illness in patients with COVID-19.