Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

著者: Mikołaj Ogrodnik, Yi Zhu, Larissa Prata, Tamar Tchkonia, Patrick Krüger, Edward Fielder, Stella Victorelli, Rifqha A. Ruswhandi, Nino Giorgadze, Tamar Pirtskhalava, Oleg Podgorni, Grigori Enikolopov, Kurt O. Johnson, Ming Xu, Christine Inman, Allyson K. Palmer, Marissa Schafer, Moritz Weigl, Yuji Ikeno, Terry C. Burns, João F. Passos, Thomas von Zglinicki, James L. Kirkland, Diana Jurk - Cell Metabolism 2019 被引用: 541

(Cell Metabolism 29, 1061–1077.e1–e8; May 7, 2019) In the original publication of this paper, Allyson K. Palmer, who contributed to the data analysis and provided some of the db/db animals, was not included in the original list of authors. All co-authors on the manuscript have approved this addition. This has since been corrected online. The authors apologize for the error. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs NeurogenesisOgrodnik et al.Cell MetabolismJanuary 3, 2019In BriefObesity, a growing health problem in western societies, is associated with increased senescent cells and neuropsychiatric disorders, including anxiety and depression. Ogrodnik and colleagues found that clearance of senescent cells in obese mice alleviates anxiety. Our study provides proof-of-concept evidence that senolytics are a potential new therapeutic avenue for treating neuropsychiatric disorders. Full-Text PDF Open Access