Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function

著者: Yuchi Honaker, Nicholas Hubbard, Yufei Xiang, Logan Fisher, David Hagin, Karen Sommer, Yumei Song, Soo Jung Yang, Christina Lopez, Tori Tappen, Elizabeth M. Dam, Iram Khan, Malika Hale, Jane H. Buckner, Andrew M. Scharenberg, Troy R. Torgerson, David J. Rawlings - Science Translational Medicine 2020 被引用: 117

Gene editing to insert a strong promoter upstream of endogenous FOXP3 conferred T reg -like properties and functions to primary human CD4 + T cells.