Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice

著者: Jun Xu, Xiaofang Wang, Jiaye Chen, Shengbo Chen, Zhijun Li, Hongbin Liu, Yang Bai, Fachao Zhi - Theranostics 2020 被引用: 108

Intravenous infusion of T-MSCs alleviated colitis in mice by elevating the circulating IGF-1 level. Increased IGF-1 maintained the integrity of epithelial cells and contributed to their repair and regeneration. Our study has identified T- MSCs as a potential cell resource for IBD treatment.