Vitamin D3 activates the autolysosomal degradation function againstHelicobacter pylorithrough the PDIA3 receptor in gastric epithelial cells

著者: Wei Hu, Lin Zhang, Ming Xing Li, Jing Shen, Xiaodong Liu, Zhan Xiao, Ding Wu, Idy H. T. Ho, Justin C. Y. Wu, Cynthia Cheung, Yu Chen Zhang, H. Y. A. Lau, Hassan Ashktorab, Duane T. Smoot, Evandro Fei Fang, Matthew T.V. Chan, Tony Gin, Wei Gong, William Ka Kei Wu, Chi Hin Cho - Autophagy 2019 被引用: 143

; BECN1: beclin 1; CagA: cytotoxin-associated gene A; CFU: colony-forming unit; ChIP-PCR: chromatin immunoprecipitation-polymerase chain reaction; Con A: concanamycin A; CQ: chloroquine; CRISPR: clustered regularly interspaced short palindromic repeats; CTSD: cathepsin D; GPN: Gly-Phe-β-naphthylamide; H. pylori: Helicobacter pylori; LAMP1: lysosomal associated membrane protein 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MCOLN1: mucolipin 1; MCOLN3: mucolipin 3; MCU: mitochondrial calcium uniporter; MOI: multiplicity of infection; NAGLU: N-acetyl-alpha-glucosaminidase; PDIA3: protein disulfide isomerase family A member 3; PMA: phorbol 12-myristate 13-acetate; PRKC: protein kinase C; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription 3; SS1: Sydney Strain 1; TRP: transient receptor potential; VacA: vacuolating cytotoxin; VD3: vitamin D3; VDR: vitamin D receptor.