Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

著者: Berk Aykut, Ruonan Chen, Jacqueline I. Kim, Dongling Wu, Sorin A. A. Shadaloey, Raquel Abengozar, Pamela Preiss, Anjana Saxena, Smruti Pushalkar, Joshua Leinwand, Brian Diskin, Wei Wang, Gregor Werba, Matthew E. Berman, Steve Ki Buom Lee, Alireza Khodadadi‐Jamayran, Deepak Saxena, William A. Coetzee, George Miller - Science Immunology 2020 被引用: 148

is regulated via up-regulation of histone deacetylase 2. Collectively, our work uncovers Piezo1 as a targetable immune checkpoint that drives immunosuppressive myelopoiesis in cancer and infectious disease.