Aromatic Spiroketal Bisphosphine Ligands: Palladium‐Catalyzed Asymmetric Allylic Amination of Racemic Morita–Baylis–Hillman Adducts

著者: Xiaoming Wang, Fanye Meng, Yan Wang, Zhaobin Han, Xiaopeng Cheng, Li Liu, Zheng Wang, Kuiling Ding - Angewandte Chemie International Edition 2012 被引用: 210

Showing a backbone: The spiroketal backbone of the bis(phosphine) ligand 1 led to good regio- and enantioselectivity in the palladium-catalyzed asymmetric allylic amination of racemic Morita–Baylis–Hillman adducts with aromatic amines. The methodology provides a facile and efficient synthesis of precursors for optically active β-lactam derivatives, including the cholesterol drug Ezetimibe.