An Approach to Developing Cyanines with Simultaneous Intersystem Crossing Enhancement and Excited-State Lifetime Elongation for Photodynamic Antitumor Metastasis

著者: Xueze Zhao, Qichao Yao, Saran Long, Weijie Chi, Yuxin Yang, Davin Tan, Xiaogang Liu, Haiqiao Huang, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng - Journal of the American Chemical Society 2021 被引用: 204

quantum yield (4.48-fold higher than Cy5), the longest triplet-state lifetime (9.80-fold longer than Cy5), and lossless emission intensity (nearly no change compared with Cy5). Such excellent photophysical properties coupled with its inherently cationic and hydrophilic nature enable the photosensitizer to realize photoablation of solid tumor and antitumor lung metastasis. This study highlights the design of a new generation of NIR photosensitizers for imaging-guided photodynamic cancer treatment.