Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD

著者: Yunjiao Zhou, Zezhong Liu, Shibo Li, Wei Xu, Qianqian Zhang, Israel Tojal da Silva, Cheng Li, Yanling Wu, Qingling Jiang, Zhenmi Liu, Qiujing Wang, Yu Guo, Jianbo Wu, Chenjian Gu, Xia Cai, Di Qu, Christian T. Mayer, Xiangxi Wang, Shibo Jiang, Tianlei Ying, Zhenghong Yuan, Youhua Xie, Yumei Wen, Lu Lu, Qiao Wang - Cell Reports 2021 被引用: 142

(50% inhibitory concentration) values as low as 5.1 and 23.7 ng/mL, while not exhibiting ADE. Therefore, neutralization and ADE of human SARS-CoV-2 antibodies correlate with non-overlapping RBD epitopes.