Shisa7 is a GABA A receptor auxiliary subunit controlling benzodiazepine actions

著者: Wenyan Han, Jun Li, Kenneth A. Pelkey, Saurabh Pandey, Xiumin Chen, Yaxian Wang, Kunwei Wu, Lihao Ge, Tianming Li, David Castellano, Chengyu Liu, Ling‐Gang Wu, Ronald S. Petralia, Joseph W. Lynch, Chris J. McBain, Wei Lü - Science 2019 被引用: 102

Fine control of brain GABA A receptors GABA A (γ-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han et al. investigated if a protein called SHISA7 was involved in regulating GABA A receptor expression and function (see the Perspective by Rudolph and Moss). SHISA7 was found at GABA-releasing synapses, where it interacted with GABA A receptors, controlled receptor concentration at the synapse, sped up receptor deactivation kinetics, and modulated some behavioral properties of benzodiazepines. SHISA7 thus affects surface expression, gating kinetics, and pharmacology of GABA A receptors in the brain. Science , this issue p. 246 ; see also p. 185