2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

著者: Thorsten Simon, Barbara Hero, Johannes H. Schulte, Hedwig E. Deubzer, Patrick Hundsdoerfer, Dietrich von Schweinitz, Jörg Fuchs, Matthias Schmidt, Vikas Prasad, B. Krug, Beate Timmermann, Ivo Leuschner, Matthias Fischer, Thorsten Langer, Kathy Astrahantseff, Frank Berthold, Holger N. Lode, Angelika Eggert - Klinische Pädiatrie 2017 被引用: 104

The clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.