Characterization of Nucleic Acids by Nanopore Analysis

著者: David W. Deamer, Daniel Branton - Accounts of Chemical Research 2002 被引用: 501

Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.