Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline forCYP2D6genotype and use of ondansetron and tropisetron

著者: GC Bell, KE Caudle, Michelle Whirl‐Carrillo, RJ Gordon, Keiko Hikino, CA Prows, Andrea Gaedigk, JAG Agundez, Senthilkumar Sadhasivam, Teri E. Klein, Matthias Schwab - Clinical Pharmacology & Therapeutics 2016 被引用: 216

5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are used in the prevention of chemotherapy- induced, radiation-induced and postoperative nausea and vomiting. CYP2D6 polymorphisms can influence the metabolism of some of these drugs (i.e. ondansetron and tropisetron) thereby affecting drug efficacy. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for ondansetron and tropisetron based on CYP2D6 genotype (updates at www.pharmgkb.org).