A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

著者: Tyson R. Chiaro, Ray Soto, W. Zac Stephens, Jason L. Kubinak, Charisse Petersen, Lasha Gogokhia, Rickesha Bell, Julio C. Delgado, James E. Cox, Warren P. Voth, Jessica C. S. Brown, David J. Stillman, Ryan M. O’Connell, Anne E. Tebo, June L. Round - Science Translational Medicine 2017 被引用: 228

in mice. In addition, we found a positive correlation between elevated uric acid and anti-yeast antibodies in human sera. Thus, yeast in the gut may be able to potentiate metabolite production that negatively affects the course of inflammatory bowel disease.