High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines

著者: Kathryn A. Pape, Thamotharampillai Dileepan, Amanda J. Kabage, Daria Kozysa, Rodolfo Batres, Clayton Evert, Michael Matson, Sharon Lopez, P. Krueger, Carolyn Graiziger, Byron P. Vaughn, Eugenia Shmidt, Joshua Rhein, Timothy W. Schacker, Alexander Khoruts, Marc K. Jenkins - Cell Reports 2021 被引用: 112

and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses.