High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds

著者: Mattia Zampieri, Balázs Szappanos, María V. Buchieri, Andrej Trauner, Ilaria Piazza, Paola Picotti, Sébastien Gagneux, Sònia Borrell, Brigitte Gicquel, Joël Lelièvre, Balázs Papp, Uwe Sauer - Science Translational Medicine 2018 被引用: 138

and in vitro compound-proteome interaction analysis for one of these compounds. Our compendium of drug-metabolome profiles can be used to rapidly query the MoAs of uncharacterized antimicrobial compounds and should be a useful resource for the drug discovery community.