B cell superantigens in the human intestinal microbiota

著者: Jeffrey J. Bunker, Christoph Drees, Andrea R. Watson, Catherine H. Plunkett, Cathryn R. Nagler, Olaf Schneewind, A. Murat Eren, Albert Bendelac - Science Translational Medicine 2019 被引用: 108

that bind IgA variable regions and stimulate potent IgA responses in mice. These superantigens stimulate B cells expressing human VH3 or murine VH5/6/7 variable regions and subsequently bind their antibodies, allowing these microbial organisms to become highly coated with IgA in vivo. These findings demonstrate a previously unappreciated role for commensal superantigens in host-microbiota interactions. Furthermore, as superantigen-expressing strains show an uneven distribution across human populations, they should be systematically considered in studies evaluating human B cell responses and microbiota during homeostasis and disease.