FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

著者: Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, Jiahui Yao, Min Zhang, Kai Xia, Xin Feng, Yanqing Li, Xiaoyan Liang, Xiangzhou Sun, Chunhua Deng, Guihua Liu - Aging 2020 被引用: 94

model, we observed that FOXO4 maintains the viability of senescent Leydig cells and suppresses their apoptosis. By disrupting the FOXO4-p53 interaction, FOXO4-DRI, a specific FOXO4 blocker, selectively induced p53 nuclear exclusion and apoptosis in senescent Leydig cells. In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency. These findings reveal the therapeutic potential of FOXO4-DRI for the treatment of male late-onset hypogonadism.