Childhood trauma history is linked to abnormal brain connectivity in major depression

著者: Meichen Yu, Kristin A. Linn, Russell T. Shinohara, Desmond J. Oathes, Philip A. Cook, Romain Duprat, Tyler M. Moore, María A. Oquendo, Mary L. Phillips, Melvin G. McInnis, Maurizio Fava, Madhukar H. Trivedi, Patrick J. McGrath, Ramin V. Parsey, Myrna M. Weissman, Yvette I. Sheline - Proceedings of the National Academy of Sciences, PNAS 2019 被引用: 237

) higher within-network connectivity in two sensory networks [sensorimotor network (SMN) and visual network (VIS)]. Furthermore, we found significant alterations in connectivity between a number of these networks. Among patients with MDD, a history of childhood trauma and current symptoms quantified by clinical assessments were associated with a multivariate pattern of seven different within- and between-network connectivities involving the DAN, FPN, CON, subcortical regions, ventral attention network (VAN), auditory network (AUD), VIS, and SMN. Overall, our study showed that traumatic childhood experiences and dimensional symptoms are linked to abnormal network architecture in MDD. Our results suggest that RSN connectivity may explain underlying neurobiological mechanisms of MDD symptoms and has the potential to serve as an effective diagnostic biomarker.