Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

著者: Kai Wang, Ruei‐Zeng Lin, Xuechong Hong, Alex H. M. Ng, Chin Nien Lee, Joseph Neumeyer, Gang Wang, Xi Wang, Minglin Ma, William T. Pu, George M. Church, Juan M. Melero‐Martin - Science Advances 2020 被引用: 132

was critical, and bypassing the mesodermal stage produced putative h-iECs with reduced expansion potential and inability to form functional vessels. Our protocol has broad applications and could reliably provide an unlimited number of h-iECs for vascular therapies.