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著者: Xiaofang Liu, Mengchuan Luo, Huanyu Meng, Qiuming Zeng, Liqun Xu, Bo Hu, Yue‐Bei Luo, Chang Liu, Zhaohui Luo, Huan Yang, S Berrih-Aknin, M Frenkian-Cuvelier, B Eymard, N Gilhus, Myasthenia Gravis, S Monticelli, B Chu, L Zhong, S Dou, J Wang, J Li, M Wang, Q Shi, Y Mei, M Wu, G Fu, V Rybakin, J Brzostek, W Paster, O Acuto, N Gascoigne, X Liu, R Wang, B Hu, M Luo, Q Zeng, H Zhou, K Huang, X Dong, Y Luo, Z Luo, H Yang, C Chen, S Schaffert, R Fragoso, C Loh, Z Yang, X Wan, Z Gu, H Zhang, X Yang, L He, R Miao, Y Zhong, H Zhao, N Gilhus, J Verschuuren, Z Luo, Y Li, X Liu, M Luo, L Xu, Y Luo, B Xiao, H Yang, X Liu, Y Luo, Z Luo, H Yang, M Pagani, G Rossetti, I Panzeri, P De Candia, R Bonnal, R Rossi, J Geginat, S Abrignani, Y Zhang, Z Feng, G Naselli, F Bell, J Wettenhall, P Auyeung, J Ellis, A Ponsonby, T Speed, M Chong, L Harrison, Y Zhang, M Guo, N Xin, Z Shao, X Zhang, Y Zhang, J Chen, S Zheng, L Fu, Y Wang, D Zhou, H Chen, Y Huang, R Dong, C Xiao, Y Liu, D Geng, A Jaretzki, R Barohn, R Ernstoff, H Kaminski, J Keesey, A Penn, D Sanders, Q Li, J Chau, P Ebert, G Sylvester, H Min, G Liu, R Braich, M Manoharan, J Soutschek, P Skare, L Klein, M Davis, C Chen, W Sang, C Zhang, D Zhang, Y Wang, C Sun, M Niu, X Sun, C Zhou, L Zeng, B Pan, W Chen, D Yan, F Zhu, Q Wu, J Cao, K Zhao, C Chen, Z Li, D Li, T Loughran, Jr, K Xu, O Boyman, J Sprent, W Liao, J Lin, W Leonard, Y Shumei, L Yi, M Huanyu, L Zhibin, J Wanlin, X Liqun, Y Huan, J Bluestone, N Crellin, E Trotta, R Huda, R Strait, E Tuzun, F Finkelman, P Christadoss, B Wu, E Goluszko, R Huda, E Tuzun, P Christadoss, M Meriggioli, D Sanders, E Frisaldi, A Shaibani, J Vollert, B Ferrero, R Carrino, H Ibraheem, L Vase, F Benedetti, R Bedlack, D Simel, H Bosworth, G Samsa, B Tucker-Lipscomb, D Sanders, H Yang, M Kala, B Scott, E Goluszko, H Chapman, P Christadoss, E Tuzun, S Berrih-Aknin, T Brenner, L Kusner, R Le Panse, H Yang, S Tzartos, P Christadoss, Z Luo, Y Dai, L Zhang, C Jiang, Z Li, J Yang, J Mccarthy, X She, W Zhang, J Ma, W Xiong, M Wu, J Lu, X Li, X Li, J Xiang, G Li, M Luo, X Liu, H Meng, L Xu, Y Li, Z Li, C Liu, Y Luo, B Hu, Y Xue, Y Liu, Z Luo, H Yang - European Journal of Immunology 2019 被引用: 17

have been reported to play crucial roles in immune responses and other biological processes, but the role of miR-181a in myasthenia gravis (MG) has been relatively less studied. We found that miR-181a was downregulated in the peripheral blood mononuclear cells (PBMCs) of MG patients and was associated with QMGs and anti-AChR Ab levels. In vitro experiments indicated that miR-181a was involved in the modulation of CD4 + T cell activation and plasticity and that miR-181a the expression level of the Th1-related transcription factor T-bet and the Th17-related transcription factor RORt. In the in vivo experiment, miR-181a treatment alleviated experimental autoimmune myasthenia gravis (EAMG) symptoms and affected both CD4 + T cell differentiation and the production of anti-AChR antibodies. Moreover, in this study, we also found that IL-2 was 15214141, ja, Downloaded from https://onlinelibrary.wiley.com/