A first update on mapping the human genetic architecture of COVID-19

著者: COVID-19 Host Genetics Initiative, COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha Karjalainen, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, Manuscript analyses team members: PHEWAS, Renato Polimanti, Manuscript analyses team members: Mendelian randomization, Nadia V. Harerimana, Manuscript analyses team members: methods development, Matti Pirinen, Manuscript analyses team members: PC projection, gene prioritization, Project management group, Project management lead, Rachel G. Liao, Project managment support, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Website development, Huy Nguyen, Matthew Solomonson, Scientific communication group, Scientific communication lead, Kumar Veerapen, Brooke Wolford, Analysis Team Lead, Genevieve Roberts, Data collection lead, Danny Park, Admin team lead, Catherine A. Ball, Analysis team member, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Data collection member, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Admin team member, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, BelCovid, Analysis team lead, Mari Niemi, Data collection lead, Souad Rahmouni, Julien Guntz, Admin team lead, Y Beguin, Analysis team member, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Data collection member, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Stéphanie Gofflot, Sabine Claassen, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Léonard, Frédéric Frippiat, Jean‐Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Yasmine Belhaj, Bernard Lambermont, Biobanque Quebec COVID-19, Analysis team lead, Tomoko Nakanishi, Data collection lead, David Morrison, Admin team lead, Vincent Mooser, J. Brent Richards, Analysis team member, Guillaume Butler‐Laporte, Vincenzo Forgetta, Rui Li, Data collection member, Biswarup Ghosh, Lætitia Laurent, Alexandre Bélisle, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madéleine Durand, Admin team member, Erwin Schurr, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, Michaël Chassé, Daniel E. Kaufmann, G. Mark Lathrop, Darin Adra, CCHC COVID-19 GAWS, Analysis team lead, Caroline Hayward, Joseph Glessner, Douglas M. Shaw, Data collection lead, Archie Campbell, Marcela Morris, Admin team lead, Håkon Håkonarson, David J. Porteous, Jennifer E. Below, Analysis team member, Anne Richmond, Xiao Chang, Hannah Polikowski, Petty E. Lauren, Hung‐Hsin Chen, Wanying Zhu, Data collection member, Chloe Fawns‐Ritchie, Admin team member, Kari E. North, Joseph B. McCormick, CHOP CAG, Data collection member, Xiao Chang, Joseph R. Glessner, Håkon Håkonarson, Analysis team lead, Christopher R. Gignoux, Data collection lead, Stephen J. Wicks, Kristy Crooks, Admin team lead, Kathleen C. Barnes, Analysis team member, Michelle Daya, Jonathan Shortt, Nicholas Rafaels, Sameer Chavan, Coronagenes, Analysis team lead, Paul R. H. J. Timmers, James F. Wilson, Albert Tenesa, Admin team lead, Shona M. Kerr, Analysis team member, Kenton D’Mellow, Egypt hgCOVID hub, Analysis team lead, Data collection lead, Doaa Shahin, Yasser M. El‐Sherbiny, Admin team lead, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M. Eltoukhy, Analysis team member, Lindokuhle Nkambul, Data collection member, Tamer Elhadidy, Mohamed S. Abd Elghafar, Jehan J. El‐Jawhari, Attia A. S. Mohamed, Marwa H. Elnagdy, Amr Samir, Mahmoud Abdel-Aziz, Walid T. Khafaga, Walaa M. El-Lawaty, Mohamed Torky, Mohamed El‐Shanshory, Admin team member, Amr M. Yassen, M. Hegazy, Kamal Okasha, Mohammed Eid, Hanteera S. Moahmed, EraCORE, Analysis team lead, Carolina Medina‐Gómez, Data collection lead, M. Arfan Ikram, Admin team lead, André G. Uitterlinden, Estonian Biobank, Analysis team lead, Reedik Mägi, Data collection lead, Lili Milani, Admin team lead, Andres Metspalu, Analysis team member, Triin Laisk, Kristi Läll, Maarja Lepamets, Data collection member, Tõnu Esko, Ene Reimann, Paul Naaber, Edward Laane, Jaana Pesukova, Pärt Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Admin team member, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, EXCEED, Analysis team lead, Chiara Batini, Data collection lead, Martin D. Tobin, Admin team lead, Laura D. Venn, Analysis team member, Paul H. Lee, Nick Shrine, Alexander T. Williams, Data collection member, Anna L. Guyatt, Catherine John, Richard Packer, Altaf Ali, Robert C. Free, Xueyang Wang, Louise V. Wain, Edward J. Hollox, Admin team member, Catherine Bee, Emma L. Adams, FinnGen, Aarno Palotie, Analysis team member, Samuli Ripatti, Sanni Ruotsalainen, Data collection member, Kati Kristiansson, Sami Koskelainen, Markus Perola, Kati Donner, Katja Kivinen, Aarno Palotie, Admin team member, Mari Kaunisto, Functional Host Genomics in Infectious Diseases (FHoGID), Analysis team lead, Carlo Rivolta, Data collection lead, Pierre-Yves Bochud, Stéphanie Bibert, Noémie Boillat‐Blanco, Semira Gonseth, Werner C. Albrich, Analysis team member, Mathieu Quinodoz, Dhryata Kamdar, Data collection member, Noémie Suh, Dionysios Neofytos, Véronique Erard, Cathy Voide, FHoGID, Pierre-Yves Bochud, Carlo Rivolta, Stéphanie Bibert, Mathieu Quinodoz, Dhryata Kamdar, Dionysios Neofytos, Véronique Erard, Cathy Voide, R. Friolet, P. Vollenweider, J. L. Pagani, Mauro Oddo, Friederike Meyer zu Bentrup, A. Conen, Olivier Clerc, Oscar Marchetti, A. Guillet, C. Guyat-Jacques, S. Foucras, M. Rime, J. Chassot, M. Jaquet, R. Merlet Viollet, Y. Lannepoudenx, L. Portopena, RegCOVID, P. Y. Bochud, P. Vollenweider, J. L. Pagani, F. Desgranges, Paraskevas Filippidis, Benoît Guéry, David Haefliger, Eleftheria Kampouri, Oriol Manuel, Aline Munting, Matthaios Papadimitriou‐Olivgeris, Jean Regina, L. Rochat-Stettler, V. Suttels, Eliana Tadini, J Tschopp, Mathias Van Singer, Benjamin Viala, P-PredictUs, Noémie Boillat‐Blanco, T. Brahier, Olivier Hügli, J. Y. Meuwly, O. Pantet, SeroCOVID, Semira Gonseth, Pierre–Yves Bochud, Valérie D’Acremont, S. Estoppey Younes, CRiPSI, Werner C. Albrich, Noémie Suh, A. Cerny, L. O’Mahony, C. von Mering, P. Y. Bochud, Mirjam Frischknecht, G-R. Kleger, M. Filipovic, C. R. Kahlert, Hannah Wozniak, Tommaso Rochat Negro, J. Pugin, Konstantinos Bouras, C. Knapp, Thomas Egger, A. Perret, P. Montillier, C. di Bartolomeo, Beatrice Barda, GCAT Genomes For Life, Analysis team lead, Rafael de Cid, Data collection lead, Anna Carreras, Vı́ctor Moreno, Manolis Kogevinas, Analysis team member, Iván Galván‐Femenía, Natàlia Blay, Xavier Farré, Lauro Sumoy, Data collection member, Beatriz Cortés, Josep M. Mercader, Marta Guindo-Martínez, David Torrents, Judith García‐Aymerich, Gemma Castaño‐Vinyals, Carlota Dobaño, Analysis team lead, Marco Gori, Data collection lead, Alessandra Renieri, Francesca Mari, Mario U. Mondelli, Francesco Castelli, Massimo Vaghi, Stefano Rusconi, Francesca Montagnani, Elena Bargagli, Federico Franchi, Maria Antonietta Mazzei, Luca Cantarini, Danilo Tacconi, Marco Feri, Raffaele Scala, Genni Spargi, Cesira Nencioni, Maria Bandini, Gian Piero Caldarelli, Anna Canaccini, Agostino Ognibene, Antonella d’Arminio Monforte, Massimo Girardis, Andrea Antinori, Daniela Francisci, Elisabetta Schiaroli, Pier Giorgio Scotton, Sandro Panese, Renzo Scaggiante, Matteo Della Monica, Mario Capasso, Giuseppe Fiorentino, Marco Castori, Filippo Aucella, Antonio Di Biagio, Luca Masucci, Serafina Valente, Marco Mandalà, Patrizia Zucchi, Ferdinando Giannattasio, Domenico Coviello, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Marco Rizzi, Maria Teresa La Rovere, Simona Sarzi Braga, Maurizio Bussotti, Sabrina Ravaglia, Rosangela Artuso, Antonio Perrella, Davide Romani, Paola Bergomi, E Catena, Antonella Vincenti, Claudio Ferri, Davide Grassi, G Pessina, Mario Tumbarello, Massimo Di Pietro, Sabrina Ravaglia, Sauro Luchi, Admin team lead, Simone Furini, Simona Dei, Analysis team member, Elisa Benetti, Nicola Picchiotti, Maurizio Sanarico, Stefano Ceri, Pietro Pinoli, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Kristina Zguro, Katia Capitani, Lindokuhle Nkambule, Marco Tanfoni, Data collection member, Chiara Fallerini, Sergio Daga, Margherita Baldassarri, Francesca Fava, Elisa Frullanti, Floriana Valentino, Gabriella Doddato, Annarita Giliberti, Rossella Tita, Sara Amitrano, Mirella Bruttini, Susanna Croci, Ilaria Meloni, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Giada Beligni, Andréa Tommasi, Laura Di Sarno, Maria Palmieri, Miriam Lucia Carriero, Diana Alaverdian, Stefano Busani, Raffaele Bruno, Marco Vecchia, Mary Ann Belli, Stefania Mantovani, Serena Ludovisi, Eugenia Quirós-Roldán, Melania Degli Antoni, Isabella Zanella, Matteo Siano, Arianna Emiliozzi, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Susanna Guerrini, Edoardo Conticini, Bruno Frediani, Chiara Spertilli, Alice Donati, Luca Guidelli, Marta Corridi, Leonardo Croci, Paolo Piacentini, Elena Desanctis, Silvia Cappelli, Agnese Verzuri, Valentina Anemoli, Alessandro Pancrazzi, Maria Lorubbio, Federica Gaia Miraglia, Sophie Venturelli, Andrea Cossarizza, Alessandra Vergori, Arianna Gabrieli, Agostino Riva, Francesco Paciosi, Francesca Andretta, Francesca Gatti, Saverio Giuseppe Parisi, Stefano Baratti, Carmelo Piscopo, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Massimo Carella, Giuseppe Merla, Gabriella Maria Squeo, Pamela Raggi, Carmen Marciano, Rita Perna, Matteo Bassetti, Maurizio Sanguinetti, Alessia Giorli, Lorenzo Salerni, Pierpaolo Parravicini, E. Menatti, Tullio Trotta, Gabriella Coiro, Fabio Lena, Enrico Martinelli, Sandro Mancarella, Chiara Gabbi, Franco Maggiolo, Diego Ripamonti, Tiziana Bachetti, Claudia Suardi, Gianfranco Parati, Giordano Bottà, Paolo Di Domenico, Ilaria Rancan, Francesco Paolo Bianchi, Riccardo Colombo, Chiara Barbieri, Donatella Acquilini, Elena Andreucci, Francesco Vladimiro Segala, Giusy Tiseo, Marco Falcone, Mirjam Lista, Monica Poscente, Oreste De Vivo, Paola Petrocelli, Alessandra Guarnaccia, Silvia Baroni, Generation Scotland, Analysis team lead, Caroline Hayward, Data collection lead, David J. Porteous, Admin team lead, Chloe Fawns‐Ritchie, Analysis team member, Anne Richmond, Data collection member, Archie Campbell, Genes & Health, Analysis team lead, David A. van Heel, Data collection lead, Karen A. Hunt, Admin team lead, Richard C. Trembath, Analysis team member, Qin Qin Huang, Hilary C. Martin, Data collection member, Dan Mason, Bhavi Trivedi, John Wright, Admin team member, Sarah Finer, Shaheen Akhtar, Mohammad Yaser Anwar, Elena Arciero, Samina Ashraf, Gerome Breen, Raymond T. Chung, Charles Curtis, Maharun Chowdhury, Grainne Colligan, Panos Deloukas, Ceri Durham, Sarah Finer, Chris Griffiths, Qin Qin Huang, Matt Hurles, Karen A. Hunt, Shapna Hussain, Kamrul Islam, Ahsan Ali Khan, Amara Khan, Cath Lavery, Sang Hyuck Lee, Robin G. Lerner, Daniel G. MacArthur, Bev MacLaughlin, Hilary C. Martin, Dan Mason, Shefa Miah, Bill Newman, Nishat Safa, Farah Tahmasebi, Richard C. Trembath, Bhavi Trivedi, David A. van Heel, John Wright, Chris Griffiths, Genes for Good, Analysis team lead, Albert V. Smith, Data collection member, Andrew P. Boughton, Kevin Li, Jonathon LeFaive, Aubrey Annis, Genome-wide assessment of the gene variants associated with severe COVID-19 phenotype in Iran, Analysis team lead, Ahmadreza Niavarani, Data collection lead, Rasoul Aliannejad, Analysis team member, Bahareh Sharififard, Data collection member, Ali Amirsavadkouhi, Zeinab Naderpour, Hengameh Ansari Tadi, Afshar Etemadi-Aleagha, Saeideh Ahmadi, Seyed Behrooz Mohseni Moghaddam, Alireza Adamsara, Morteza Saeedi, Hamed Abdollahi, Abdolmajid Hosseini, Host genetic factors in COVID-19 patients in relation to disease susceptibility, disease severity and pharmacogenomics, Analysis team lead, Pajaree Chariyavilaskul, Data collection lead, Watsamon Jantarabenjakul, Admin team lead, Nattiya Hirankarn, Analysis team member, Monpat Chamnanphon, Thitima B. Suttichet, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Data collection member, Opass Putchareon, Pattama Torvorapanit, Thanyawee Puthanakit, Pintip Suchartlikitwong, Admin team member, Voraphoj Nilaratanakul, Pimpayao Sodsai, HUNT, Analysis team lead, Ben Brumpton, Data collection lead, Kristian Hveem, Cristen J. Willer, Analysis team member, Brooke Wolford, Wei Zhou, Data collection member, Tormod Rogne, Erik Solligård, Bjørn Olav Åsvold, Lifelines, Analysis team lead, Lude Franke, Data collection lead, Marike Boezen, Analysis team member, Patrick Deelen, Annique Claringbould, Esteban Lopera, Robert Warmerdam, Judith M. Vonk, Irene V. van Blokland, Data collection member, Pauline Lanting, Anil P. S. Ori, Mass General Brigham-Host Vulnerability to COVID-19, Analysis team lead, Yen‐Chen Anne Feng, Josep M. Mercader, Data collection lead, Scott T. Weiss, Elizabeth W. Karlson, Jordan W. Smoller, Shawn N. Murphy, James B. Meigs, Ann E. Woolley, Admin team lead, Robert C. Green, Data collection member, Emma Perez, Michigan Genomics Initiative, Analysis team lead, Brooke N. Wolford, Admin team lead, Sebastian Zöllner, Analysis team member, Jiongming Wang, Andrew F. Beck, Mount Sinai Health System COVID-19 Genomics Initiative, Analysis team lead, Laura Sloofman, Data collection lead, Steven Ascolillo, Robert Sebra, Brett Collins, Tess Levy, Admin team lead, Joseph D. Buxbaum, Stuart C. Sealfon, Analysis team member, Daniel M. Jordan, Ryan C. Thompson, Kyle Gettler, Kumardeep Chaudhary, Gillian M. Belbin, Michael Preuß, Clive Hoggart, Sam Choi, Slayton J. Underwood, Data collection member, Irene Salib, Bari Britvan, Katherine Keller, Lara Tang, Michael Peruggia, Liam L. Hiester, Kristi Niblo, Alexandra Aksentijevich, Alexander Labkowsky, Avrohom Karp, Menachem Zlatopolsky, Marissa Zyndorf, Admin team member, Alexander W. Charney, Noam D. Beckmann, Eric E. Schadt, Noura S. Abul‐Husn, Judy H. Cho, Yuval Itan, Eimear E. Kenny, Ruth J. F. Loos, Girish N. Nadkarni, Ron Do, Paul F. O’Reilly, Laura M. Huckins, MyCode Health Initiative, Analysis team lead, Manuel A. R. Ferreira, Gonçalo R. Abecasis, Data collection lead, Joseph B. Leader, Michael Cantor, Admin team lead, Anne E. Justice, Dave J. Carey, Analysis team member, Geetha Chittoor, Navya Shilpa Josyula, Jack A. Kosmicki, Julie Horowitz, Aris Baras, Data collection member, Matthew C. Gass, Ashish Yadav, Admin team member, Tooraj Mirshahi, Netherlands Twin Register, Analysis team lead, Jouke Jan Hottenga, Data collection lead, Meike Bartels, Admin team lead, Eco J. C. de Geus, Analysis team member, Michel G. Nivard, Penn Medicine Biobank, Analysis team lead, Anurag Verma, Marylyn D. Ritchie, Admin team lead, Daniel J. Rader, Analysis team member, Binglan Li, Shefali S. Verma, Anastasia Lucas, Yuki Bradford, Saudi Human Genome Program - COVID19: Host Genomic markers predicting the severity and suitability to COVID-19 in highly consanguineous population, Analysis team lead, Malak Abedalthagafi, Manal Alaamery, Data collection lead, Abdulraheem Alshareef, Mona Sawaji, Admin team lead, Salam Massadeh, Abdulaziz Almalik, Analysis team member, Saleh A. Alqahtani, Dona Baraka, Fawz Al Harthi, Ebtehal Alsolm, Leen Abu Safieh, Albandary M. Alowayn, Fatimah Alqubaishi, Amal Al Mutairi, Serghei Mangul, Data collection member, Mansour Almutairi, Nora Aljawini, Nour Albesher, Yaseen M. Arabi, Ebrahim Mahmoud, Amin Khattab, Roaa T. Halawani, Ziab Z. Alahmadey, Jehad K. Albakri, Walaa A. Felemban, Bandar A. Suliman, Rana Hasanato, Laila Alawdah, Jahad Alghamdi, Deema AlZahrani, Sameera Aljohani, Hani Al-Afghani, Nouf AlDhawi, Hadeel AlBardis, Sarah Alkwai, Moneera Alswailm, Faisal A. Almalki, Maha Albeladi, Iman Almohammed, Eman Barhoush, Anoud Albader, Admin team member, Sara Jeza Alotaibi, Bader Alghamdi, Junghyun Jung, Mohammad Fawzy, Data collection member, May Alrashed, The genetic predisposition to severe COVID-19, Analysis team lead, Data collection lead, Hugo Zeberg, Analysis team member, Lindo Nkambul, Data collection member, Robert Frithiof, Michael Hultström, Miklós Lipcsey, Nicolas Tardif, Olav Rooyackers, Jonathan Grip, Tomislav Maričić, The Norwegian Mother, Father and Child Cohort Study, Analysis team lead, Øyvind Helgeland, Data collection lead, Per Magnus, Lill-Iren S. Trogstad, Analysis team member, Yunsung Lee, Admin team member, Jennifer R. Harris, TwinsUK, Analysis team lead, Massimo Mangino, Data collection lead, Tim D. Spector, Data collection member, Duncan Emma, UK 100,000 Genomes Project (Genomics England), Analysis team lead, Loukas Moutsianas, Data collection lead, Mark J. Caulfield, Richard H. Scott, Analysis team member, Athanasios Kousathanas, Dorota Pasko, Susan Walker, Alexander Stuckey, Christopher A. Odhams, Daniel R. Rhodes, Data collection member, Tom Fowler, Augusto Rendon, G. C. Chan, Prabhu Arumugam, UK Biobank, Analysis team lead, Konrad J. Karczewski, Alicia R. Martin, Daniel J. Wilson, Chris C.A. Spencer, Data collection lead, Derrick W. Crook, David Wyllie, Anne Marie O’Connell, Admin team lead, Analysis team member, Elizabeth G. Atkinson, Masahiro Kanai, Kristin Tsuo, Nikolas Baya, Patrick Turley, Rahul Gupta, Raymond K. Walters, Duncan S. Palmer, Gopal Sarma, Matthew Solomonson, Nathan Cheng, Wenhan Lu, Claire Churchhouse, Jacqueline I. Goldstein, Daniel L. King, Wei Zhou, Cotton Seed, Mark J. Daly, Benjamin M. Neale, Hilary K. Finucane, Sam Bryant, F. Kyle Satterstrom, Gavin Band, Sarah G. Earle, Shang‐Kuan Lin, Nicolas Arning, Nils Koelling, Data collection member, Jacob Armstrong, Justine Rudkin, Admin team member, Shawneequa Callier, Sam Bryant, Caroline Cusick, UK Blood Donors Cohort, Analysis team lead, Nicole Soranzo, Jing Zhao, Data collection lead, John Danesh, Emanuele Di Angelantonio, Analysis team member, Adam S. Butterworth, Million Veteran Program, Analysis team lead, Yan V. Sun, Jennifer E. Huffman, Data collection lead, Kelly Cho, Admin team lead, Christopher J. O’Donnell, Philip S. Tsao, J. Michael Gaziano, Analysis team member, Gina M. Peloso, Data collection member, Yuk‐Lam Ho, Vanda COVID, Analysis team lead, Sandra Smieszek, Admin team lead, Christos Polymeropoulos, Vasilios M. Polymeropoulos, Mihael H. Polymeropoulos, Analysis team member, Bartlomiej Przychodzen, Variability in immune response genes and severity of SARS-CoV-2 infection (INMUNGEN-CoV2 study), Analysis team lead, Israel Fernández‐Cadenas, Data collection lead, Anna M. Planas, Analysis team member, Jordi Pérez‐Tur, Laia Llucià‐Carol, Natàlia Cullell, Elena Muiño, Jara Cárcel‐Márquez, Marta L. DeDiego, L. Lloret Iglesias, Data collection member, Àlex Soriano, Verónica Rico, Daiana Agüero, Josep Lluís Bedini, Francisco Lozano, Carlos Domingo, Verónica Robles, Francisca Ruíz-Jaén, Leonardo Márquez, Juan Manuel López Gómez, Eliécer Coto, Guillermo M. Albaiceta, Marta García‐Clemente, David Dalmau, María J. Arranz, Beatriz Dietl, Alex Serra-Llovich, Pere Soler, Roger Colobrán, Andrea Martín‐Nalda, Alba Parra-Martínez, David Bernardo, Silvia Rojo, Aida Fiz‐López, Elisa Arribas‐Rodríguez, Paloma Cal‐Sabater, Tomás Segura, Esther González-Villa, Gemma Serrano‐Heras, Joan Martí‐Fábregas, Elena Jiménez‐Xarrié, Alicia de Felipe Mimbrera, Jaime Masjuán, Sebastián García‐Madrona, Anna Domínguez-Mayoral, Joan Montaner Villalonga, Paloma Menéndez-Valladares, Women’s Genome Health Stud, Analysis team lead, Daniel I. Chasman, Data collection lead, Howard D. Sesso, JoAnn E. Manson, Admin team lead, Julie E. Buring, Paul M. Ridker, Analysis team member, Franco Giulianini, Phenotype steering group, Lea K. Davis, Sulggi A. Lee, James R. Priest, Vijay G. Sankaran, David A. van Heel, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, COVID-19 HGI corresponding authors - Nature 2022 被引用: 174

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1 . Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2 . Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity